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   Articles with "hotair" as a keyword



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Rs4759314 polymorphism located in HOTAIR is associated with the risk of congenital heart disease by alternating downstream signaling via reducing its expression

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.26736

Abstract: Our study was aimed to investigate the mechanism of rs4759314 located in HOTAIR involved in congenital heart disease. Luciferase assay was performed to evaluate whether rs4759314 affected the transcription efficiency of HOTAIR promoter, and confirm… read more here.

Keywords: heart disease; hotair; congenital heart; mir 545 ... See more keywords
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lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells

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recommendations! Published in 2019 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.29129

Abstract: Intervertebral disc degeneration (IDD) is a complex and chronic disease that involves disc cell senescence, death, and extracellular matrix (ECM) degradation. HOTAIR, a long non‐coding RNA (lncRNA) is reportedly associated with autophagy, whereas autophagy is… read more here.

Keywords: apoptosis senescence; hotair; senescence; pulposus cells ... See more keywords
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Dysregulated expression but redundant function of the long non-coding RNA HOTAIR in diabetic kidney disease

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recommendations! Published in 2019 at "Diabetologia"

DOI: 10.1007/s00125-019-4967-1

Abstract: Long non-coding RNAs (lncRNAs) are garnering increasing attention for their putative roles in the pathogenesis of chronic diseases, including diabetic kidney disease (DKD). However, much about in vivo lncRNA functionality in the adult organism remains… read more here.

Keywords: kidney; hotair; expression; function ... See more keywords
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lncRNA HOTAIR Inhibits Mineralization in Osteoblastic Osteosarcoma Cells by Epigenetically Repressing ALPL

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recommendations! Published in 2018 at "Calcified Tissue International"

DOI: 10.1007/s00223-018-0434-0

Abstract: HOTAIR is a lncRNA that plays critical role in gene regulation and chromatin dynamics through epigenetic mechanisms. In this work we studied the physiological role of HOTAIR during the process of mineralization using osteoblastic osteosarcoma… read more here.

Keywords: mineralization osteoblastic; hotair; osteoblastic osteosarcoma; osteosarcoma cells ... See more keywords
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No association of single nucleotide polymorphisms within H19 and HOX transcript antisense RNA (HOTAIR) with genetic susceptibility to systemic lupus erythematosus, rheumatoid arthritis, and primary Sjögren’s syndrome in a Chinese Han population

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recommendations! Published in 2017 at "Clinical Rheumatology"

DOI: 10.1007/s10067-017-3833-0

Abstract: The H19 (rs2839698, rs3741219) and HOTAIR (rs920778) polymorphisms were related to many kinds of cancers. However, these polymorphisms have been scarcely explored in different autoimmune diseases. Here, we aimed to examine the association of the… read more here.

Keywords: susceptibility; systemic lupus; hotair; lupus erythematosus ... See more keywords
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Autophagy regulated by lncRNA HOTAIR contributes to the cisplatin-induced resistance in endometrial cancer cells

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recommendations! Published in 2017 at "Biotechnology Letters"

DOI: 10.1007/s10529-017-2392-4

Abstract: ObjectivesTo identify whether lncRNAs (long non-coding RNA) participate in the regulation of cisplatin-resistant induced autophagy in endometrial cancer cells.ResultsAutophagy activity was significantly boosted in cisplatin-resistant Ishikawa cells, a human endometrial cancer cell line, compared with… read more here.

Keywords: ishikawa cells; hotair; endometrial cancer; cisplatin resistant ... See more keywords
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LncRNA HOTAIR Promotes LPS-Induced Inflammation and Apoptosis of Cardiomyocytes via Lin28-Mediated PDCD4 Stability.

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recommendations! Published in 2021 at "Inflammation"

DOI: 10.1007/s10753-021-01431-0

Abstract: Sepsis is one of the primary causes of death in intensive care units. Recently, increasing evidence has identified lncRNA HOTAIR is involved in septic cardiomyopathy. However, the potential mechanism underlying HOTAIR on septic cardiomyopathy is… read more here.

Keywords: lps induced; pdcd4; apoptosis; hotair ... See more keywords
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Overexpression of HOTAIR attenuates Pi-induced vascular calcification by inhibiting Wnt/β-catenin through regulating miR-126/Klotho/SIRT1 axis.

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recommendations! Published in 2021 at "Molecular and cellular biochemistry"

DOI: 10.1007/s11010-021-04164-8

Abstract: Vascular calcification is one of the most common effects of macrovascular complications in patients in aging with chronic kidney disease and diabetes. Previous studies showed that HOTAIR attenuated vascular calcification via the Wnt/β-catenin-signaling pathway, yet… read more here.

Keywords: vascular calcification; mir 126; hotair; calcification ... See more keywords
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Effect of Sevoflurane Anesthesia on Brain Is Mediated by lncRNA HOTAIR

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recommendations! Published in 2018 at "Journal of Molecular Neuroscience"

DOI: 10.1007/s12031-018-1029-y

Abstract: Postoperative cognitive dysfunction in elderly patients has been related to neurodegenerative disorders and mortality. Sevoflurane anesthesia has been implicated in both postoperative cognitive dysfunction and neurotoxicity. Given the advantages of using inhaled anesthetics like sevoflurane,… read more here.

Keywords: sevoflurane anesthesia; hotair; cognitive dysfunction; brain ... See more keywords
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Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR‐136‐5p and long non‐coding RNA HOTAIR in cuprizone‐induced demyelination

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recommendations! Published in 2018 at "Biochemical Pharmacology"

DOI: 10.1016/j.bcp.2018.06.028

Abstract: Graphical abstract Figure. No caption available. &NA; Sulfasalazine (SF) promotes remyelination and improves the outcome of multiple sclerosis (MS) patients. However, the underlining mechanism remains elusive. Here, we examined whether SF blocks microglia switching to… read more here.

Keywords: induced demyelination; cuprizone; hotair; cuprizone induced ... See more keywords
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HOX transcript antisense RNA (HOTAIR) in cancer.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2019.04.016

Abstract: Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an oncogenic trans-acting lncRNA. The expression of HOTAIR… read more here.

Keywords: hotair; rna hotair; hox transcript; antisense rna ... See more keywords