A compendium of stable hotspots in the CHO genome.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28390
Abstract: The use of targeted integration for industrial CHO cell line development currently requires significant upfront effort to identify genomic loci capable of supporting multigram per liter therapeutic protein production from a limited number of transgene… read more here.
Keywords: compendium stable; cell; hotspot; stable hotspots ... See more keywords
Cancer Classification Through p53 Hotspot Mutations: An Ensemble Learning Approach
Sign Up to like & getrecommendations! Published in 2025 at "Cell Biology International"
DOI: 10.1002/cbin.70041
Abstract: Tumor suppressor protein p53 is attracting a lot of attention in cancer research because of its role in both tumor cell survival and apoptosis. The most frequently altered tumor suppressor gene in human cancer is… read more here.
Keywords: classification; cancer; p53; hotspot ... See more keywords
Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22326
Abstract: Cancer driver mutations (CDMs) are necessary and causal for carcinogenesis and have advantages as reporters of carcinogenic risk. However, little progress has been made toward developing measurements of CDMs as biomarkers for use in cancer… read more here.
Keywords: risk; cancer risk; cancer driver; cancer ... See more keywords
RHOBTB2 Variant p.Arg511Gln Causes Developmental and Epileptic Encephalopathy Type 64 in an Infant: A Case Report and Hotspot Variant Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.70059
Abstract: Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of brain disorders. Variants in the Rho‐related BTB domain‐containing 2 gene (RHOBTB2) can lead to DEE64, which is characterized by early‐onset epilepsy, varying degrees of motor… read more here.
Keywords: rhobtb2 variant; variant arg511gln; developmental epileptic; hotspot ... See more keywords
Highly Diverse Symbiodiniaceae Types Hosted by Corals in a Global Hotspot of Marine Biodiversity
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Ecology"
DOI: 10.1007/s00248-024-02407-x
Abstract: Symbiotic dinoflagellates in the genus Symbiodiniaceae play vital roles in promoting resilience and increasing stress tolerance in their coral hosts. While much of the world’s coral succumb to the stresses associated with increasingly severe and… read more here.
Keywords: highly diverse; biodiversity; diverse symbiodiniaceae; hotspot ... See more keywords
Explosive and binary cyclogenesis over a mid-latitude hotspot and its Rossby number dependence in an idealized general circulation model
Sign Up to like & getrecommendations! Published in 2024 at "Climate Dynamics"
DOI: 10.1007/s00382-024-07113-5
Abstract: This study presents the optimal conditions for the formation of explosive and binary cyclones over a mid-latitude hotspot in an idealized Earth-like general circulation model of variable planetary size. Multiple solutions of cyclogenesis were obtained… read more here.
Keywords: rossby number; area; general circulation; hotspot ... See more keywords
Sequence requirement of the ade6-4095 meiotic recombination hotspot in Schizosaccharomyces pombe
Sign Up to like & getrecommendations! Published in 2017 at "Genetica"
DOI: 10.1007/s10709-017-9997-3
Abstract: Homologous recombination occurs at a greatly elevated frequency in meiosis compared to mitosis and is initiated by programmed double-strand DNA breaks (DSBs). DSBs do not occur at uniform frequency throughout the genome in most organisms,… read more here.
Keywords: requirement ade6; ade6 4095; sequence requirement; recombination ... See more keywords
Towards Formal Modeling of Subnet Based Hotspot Algorithm in Wireless Sensor Networks
Sign Up to like & getrecommendations! Published in 2019 at "Wireless Personal Communications"
DOI: 10.1007/s11277-019-06346-6
Abstract: Timely partition of the whole network is extremely difficult task in dynamic large-scale wireless sensor network (WSN). A lot of existing technique that solved this issue with maintaining the network status and relevant information, but… read more here.
Keywords: wireless sensor; hotspot; sbha; subnet based ... See more keywords
Feeding and Mobility Traits Influence Grasshopper Vulnerability to Agricultural Production in the Cape Floristic Region Biodiversity Hotspot
Sign Up to like & getrecommendations! Published in 2019 at "Neotropical Entomology"
DOI: 10.1007/s13744-019-00697-2
Abstract: To be able to foretell which species will be at risk of extinction from possible expansion of agriculture into natural areas, we need to determine how land use affects animal groups especially insects with different… read more here.
Keywords: biodiversity hotspot; floristic region; mobility; cape floristic ... See more keywords
Kitam Bird Sanctuary, the only low elevation protected area of Sikkim: A conservation hotspot for butterflies in the Eastern Himalaya
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asia-Pacific Entomology"
DOI: 10.1016/j.aspen.2019.04.002
Abstract: Abstract The lowland areas of the Himalayan region are subjected to immense anthropogenic pressure because of least representation in the protected area network. Kitam Bird Sanctuary is the only representative protected area that occurs below… read more here.
Keywords: hotspot; area; protected area; kitam bird ... See more keywords
Passenger Hotspot Mutations in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.08.002
Abstract: Current statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in… read more here.
Keywords: hotspot mutations; passenger hotspot; mutations cancer; cancer ... See more keywords