A compendium of stable hotspots in the CHO genome.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.28390
Abstract: The use of targeted integration for industrial CHO cell line development currently requires significant upfront effort to identify genomic loci capable of supporting multigram per liter therapeutic protein production from a limited number of transgene… read more here.
Keywords: compendium stable; cell; hotspot; stable hotspots ... See more keywords
Rationale and Roadmap for Developing Panels of Hotspot Cancer Driver Gene Mutations as Biomarkers of Cancer Risk
Sign Up to like & getrecommendations! Published in 2019 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22326
Abstract: Cancer driver mutations (CDMs) are necessary and causal for carcinogenesis and have advantages as reporters of carcinogenic risk. However, little progress has been made toward developing measurements of CDMs as biomarkers for use in cancer… read more here.
Keywords: risk; cancer risk; cancer driver; cancer ... See more keywords
Sequence requirement of the ade6-4095 meiotic recombination hotspot in Schizosaccharomyces pombe
Sign Up to like & getrecommendations! Published in 2017 at "Genetica"
DOI: 10.1007/s10709-017-9997-3
Abstract: Homologous recombination occurs at a greatly elevated frequency in meiosis compared to mitosis and is initiated by programmed double-strand DNA breaks (DSBs). DSBs do not occur at uniform frequency throughout the genome in most organisms,… read more here.
Keywords: requirement ade6; ade6 4095; sequence requirement; recombination ... See more keywords
Towards Formal Modeling of Subnet Based Hotspot Algorithm in Wireless Sensor Networks
Sign Up to like & getrecommendations! Published in 2019 at "Wireless Personal Communications"
DOI: 10.1007/s11277-019-06346-6
Abstract: Timely partition of the whole network is extremely difficult task in dynamic large-scale wireless sensor network (WSN). A lot of existing technique that solved this issue with maintaining the network status and relevant information, but… read more here.
Keywords: wireless sensor; hotspot; sbha; subnet based ... See more keywords
Feeding and Mobility Traits Influence Grasshopper Vulnerability to Agricultural Production in the Cape Floristic Region Biodiversity Hotspot
Sign Up to like & getrecommendations! Published in 2019 at "Neotropical Entomology"
DOI: 10.1007/s13744-019-00697-2
Abstract: To be able to foretell which species will be at risk of extinction from possible expansion of agriculture into natural areas, we need to determine how land use affects animal groups especially insects with different… read more here.
Keywords: biodiversity hotspot; floristic region; mobility; cape floristic ... See more keywords
Kitam Bird Sanctuary, the only low elevation protected area of Sikkim: A conservation hotspot for butterflies in the Eastern Himalaya
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Asia-Pacific Entomology"
DOI: 10.1016/j.aspen.2019.04.002
Abstract: Abstract The lowland areas of the Himalayan region are subjected to immense anthropogenic pressure because of least representation in the protected area network. Kitam Bird Sanctuary is the only representative protected area that occurs below… read more here.
Keywords: hotspot; area; protected area; kitam bird ... See more keywords
Passenger Hotspot Mutations in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.08.002
Abstract: Current statistical models for assessing hotspot significance do not properly account for variation in site-specific mutability, thereby yielding many false-positives. We thus (i) detail a Log-normal-Poisson (LNP) background model that accounts for this variability in… read more here.
Keywords: hotspot mutations; passenger hotspot; mutations cancer; cancer ... See more keywords
Absolute plate motions relative to deep mantle plumes
Sign Up to like & getrecommendations! Published in 2018 at "Earth and Planetary Science Letters"
DOI: 10.1016/j.epsl.2018.03.021
Abstract: Abstract Advances in whole waveform seismic tomography have revealed the presence of broad mantle plumes rooted at the base of the Earth's mantle beneath major hotspots. Hotspot tracks associated with these deep mantle plumes provide… read more here.
Keywords: absolute plate; mantle plumes; deep mantle; plate motions ... See more keywords
A new multichannel method quantitating TUNEL in detached photoreceptor nuclei
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.06.028
Abstract: &NA; Nuclear co‐localization labels are critical to ocular research. Among these, the TUNEL assay has been established as a gold standard of cell death and apoptosis. While several validated computer‐based methods exist to quantitate these… read more here.
Keywords: analysis; method; counter stain; mct method ... See more keywords
Morphotectonic characteristics, distribution and probable genesis of bathymetric highs off southwest coast of India
Sign Up to like & getrecommendations! Published in 2018 at "Geomorphology"
DOI: 10.1016/j.geomorph.2018.04.015
Abstract: Abstract The western continental margin of India and the adjacent deep ocean basins were formed by break-up and separation among India, Seychelles and Madagascar since the Late Cretaceous. The initial India-Madagascar separation and the subsequent… read more here.
Keywords: bathymetric highs; genesis bathymetric; india; morphotectonic characteristics ... See more keywords
Hotspot tracks in the South Atlantic located above bands of fast flowing asthenosphere driven by waning pulsations from the African LLSVP
Sign Up to like & getrecommendations! Published in 2018 at "Gondwana Research"
DOI: 10.1016/j.gr.2017.05.014
Abstract: Abstract The location and crustal structure of hotspot tracks in the South Atlantic reflect where melts related to sluggishly flowing plume material can reach the plate surface. This raises the paradox of how long-lived, age… read more here.
Keywords: tracks south; flowing asthenosphere; african llsvp; south atlantic ... See more keywords