Integrated in silico-in vitro rational design of oncogenic EGFR-derived specific monoclonal antibody-binding peptide mimotopes.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720023500075
Abstract: Human epidermal growth factor receptor (EGFR) is strongly associated with malignant proliferation and has been established as an attractive therapeutic target of diverse cancers and used as a significant biomarker for tumor diagnosis. Over the… read more here.
Keywords: tsd; hotspot residues; formula see; see text ... See more keywords
A Sequence-segment Neighbor Encoding Schema for Protein Hotspot Residue Prediction
Sign Up to like & getrecommendations! Published in 2020 at "Current Bioinformatics"
DOI: 10.2174/1574893615666200106115421
Abstract: Hotspots are those residues that contribute major free energy of binding in protein-protein interactions. Protein functions are frequently dependent on hotspot residues. At present, hotspot residues are always identified by Alanine scanning mutagenesis technology, which… read more here.
Keywords: hotspot residues; hotspot; encoding schema; protein hotspot ... See more keywords