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   Articles with "hottip" as a keyword



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Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2018.04.173

Abstract: The spatiotemporal control of HOX gene expression is dependent on positional identity and often correlated to their genomic location within each loci. Maintenance of HOX expression patterns is under complex transcriptional and epigenetic regulation, which… read more here.

Keywords: ccctc binding; gene expression; hoxa; hottip ... See more keywords
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LncRNA HOTTIP enhances human osteogenic BMSCs differentiation via interaction with WDR5 and activation of Wnt/β-catenin signalling pathway.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.02.034

Abstract: To uncover the underlying molecular mechanism of long non-coding RNA in the osteogenic differentiation process of bone marrow mesenchymal stem cells (BMSCs), HOXA transcript at the distal tip (HOTTIP) was selected by using a lncRNA… read more here.

Keywords: catenin; hottip; differentiation; osteogenic differentiation ... See more keywords
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HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice

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recommendations! Published in 2019 at "Cancer cell"

DOI: 10.1016/j.ccell.2019.10.011

Abstract: SUMMARY Long non-coding RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism for leukemic transformation. How HOX gene-associated lncRNAs regulate hematopoietic stem cell (HSC) function and contribute to leukemogenesis… read more here.

Keywords: hottip; stem cell; self renewal; hematopoietic stem ... See more keywords
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Deregulation of long noncoding RNAs ANCR, TINCR, HOTTIP and SPRY4-IT1 in plasma of systemic sclerosis patients: SPRY4-IT1 as a novel biomarker of scleroderma and its subtypes.

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recommendations! Published in 2020 at "Cytokine"

DOI: 10.1016/j.cyto.2020.155124

Abstract: Systemic sclerosis or systemic scleroderma (SSc) is an inflammatory autoimmune disease whose pathogenesis remains ambiguous; however, epigenetics, including long noncoding RNAs (lncRNAs) is an emerging paradigm. To date, the expression, role and clinical significance of… read more here.

Keywords: ssc; ancr tincr; hottip; spry4 it1 ... See more keywords
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Long Non-Coding RNA HOTTIP is Elevated in Patients with Sepsis and Promotes Cardiac Dysfunction

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recommendations! Published in 2022 at "Immunological Investigations"

DOI: 10.1080/08820139.2022.2107932

Abstract: ABSTRACT Background Cardiac dysfunction is the most common clinical complication of sepsis. Herein, the study explored the clinical importance of long non-coding RNA (lncRNA) HOXA terminal transcript antisense RNA (HOTTIP) in the onset of sepsis… read more here.

Keywords: hottip; patients sepsis; dysfunction; cardiac dysfunction ... See more keywords
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Long-noncoding RNA HOXA transcript at the distal tip ameliorates the insulin resistance and hepatic gluconeogenesis in mice with gestational diabetes mellitus via the microRNA-423-5p/wingless-type MMTV integration site family member 7A axis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2076982

Abstract: ABSTRACT Long-noncoding RNA HOXA transcript at the distal tip (HOTTIP) has been probed to exert essential effects on diabetes progression, while its function in gestational diabetes mellitus (GDM) remains unclear. This study was committed to… read more here.

Keywords: mir 423; gdm mice; wnt7a; hottip ... See more keywords
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Fusobacterium nucleatum‐induced exosomal HOTTIP promotes gastric cancer progression through the microRNA‐885‐3p/EphB2 axis

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recommendations! Published in 2023 at "Cancer Science"

DOI: 10.1111/cas.15781

Abstract: Recent studies have reported that Fusobacterium nucleatum (Fn) is associated with gastric cancer (GC). Cancer‐derived exosomes contain key regulatory noncoding RNAs and are a crucial medium of intercellular communication. However, the function and regulatory mechanism… read more here.

Keywords: hottip; gastric cancer; exosomal hottip; 885 ephb2 ... See more keywords
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Long Noncoding RNA HOTTIP Promotes Mouse Hepatic Stellate Cell Activation via Downregulating miR-148a

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recommendations! Published in 2018 at "Cellular Physiology and Biochemistry"

DOI: 10.1159/000496012

Abstract: Background/Aims: HOTTIP is a critical modulator in human diseases including liver cancer, but its role and molecular biological mechanisms in liver fibrosis are still unclear. Methods: The expression profile of HOTTIP during the progression of… read more here.

Keywords: liver fibrosis; mir 148a; hottip; activation ... See more keywords
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lncRNA MALAT1, HOTTIP and PVT1 as predictors for predicting the efficacy of GEM based chemotherapy in first-line treatment of pancreatic cancer patients.

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.19345

Abstract: This study evaluated the lnc-RNAs as biomarker to predict efficacy of gemcitabine (GEM) based chemotherapy as the first-line treatment for locally advanced or advanced pancreatic cancer patients. We selected 62 patients with GEM based chemotherapy… read more here.

Keywords: hottip; hottip pvt1; expression; gem based ... See more keywords
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Overexpression of HOTTIP promotes proliferation and drug resistance of lung adenocarcinoma by regulating AKT signaling pathway.

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recommendations! Published in 2017 at "European review for medical and pharmacological sciences"

DOI: 10.26355/eurrev_201712_14013

Abstract: OBJECTIVE Lung adenocarcinoma is an important pathological type of lung cancer. Drug resistance is the main reason for failure of lung adenocarcinoma therapy. The purpose of this study is to explore the role of HOTTIP… read more here.

Keywords: lung adenocarcinoma; drug resistance; hottip; lung ... See more keywords
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HOTTIP Predicts Poor Survival in Gastric Cancer Patients and Contributes to Cisplatin Resistance by Sponging miR-216a-5p

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recommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2020.00348

Abstract: Gastric cancer (GC) is a significant public health burden worldwide, and cisplatin resistance is the leading cause for the failure of chemotherapy in this disease. Previous studies have revealed that HOXA transcript at the distal… read more here.

Keywords: gastric cancer; mir 216a; hottip; expression ... See more keywords