Downstream of the HOX genes: Explaining conflicting tumour suppressor and oncogenic functions in cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33949
Abstract: The HOX genes are a highly conserved group of transcription factors that have key roles in early development, but which are also highly expressed in most cancers. Many studies have found strong associative relationships between… read more here.
Keywords: tumour suppressor; hox genes; cancer; hox ... See more keywords
Noncoding RNAs within the HOX gene network in tumor pathogenesis and progression
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27036
Abstract: HOX genes are involved with normal development, cell identity, cell differentiation, cell metabolism, apoptosis, autophagy as well as with diseases such as tumor pathogenesis and progression. In particular, the genes belonging to HOX paralogous 13… read more here.
Keywords: tumor pathogenesis; progression; hox; pathogenesis progression ... See more keywords
In silico analysis of HOX-associated transcription factors as potential regulators of oral cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2021.01.002
Abstract: OBJECTIVE The objective of this study was identification of the transcription factor binding sites (TFBS) in the promoter of HOX genes and elucidation of the comprehensive interaction of transcription factors (TFs)/genes with HOX. METHODOLOGY Promoter… read more here.
Keywords: transcription; silico analysis; hox; gene ... See more keywords
Regulation of Hox and ParaHox Genes by Perfluorochemicals in Mouse Liver.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152521
Abstract: Homeobox (Hox) genes encode homeodomain proteins, which play important roles in the development and morphological diversification of organisms including plants and animals. Perfluorinated chemicals (PFCs), which are well recognized industrial pollutants and universally detected in… read more here.
Keywords: mouse livers; null mouse; hox; mrna expression ... See more keywords
The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2018.11.006
Abstract: During development diverse transcription factor inputs are integrated by cis-regulatory modules (CRMs) to yield cell-specific gene expression. Defining how CRMs recruit the appropriate combinations of factors to either activate or repress gene expression remains a… read more here.
Keywords: transcription; hox; cis regulatory; activation ... See more keywords
Breaking constraint of mammalian axial formulae
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27335-z
Abstract: The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). The genetic mechanism(s) underlying this constraint however remain ill-defined. Here,… read more here.
Keywords: hox; axial formulae; vertebral column; constraint ... See more keywords
Selective interactions between diverse STEs organize the ANT-C Hox cluster
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33588-4
Abstract: The three-dimensional organization of the eukaryotic genome is important for its structure and function. Recent studies indicate that hierarchies of chromatin loops underlie important aspects of both genomic organization and gene regulation. Looping between insulator… read more here.
Keywords: chromatin; hox; insulator; gene ... See more keywords
Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01456-5
Abstract: Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development. Post-translational modifications of histones contribute to transcriptional regulation. Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27… read more here.
Keywords: transcription; posterior hox; hox; lysine demethylase ... See more keywords
The constrained architecture of mammalian Hox gene clusters
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1904602116
Abstract: Significance Vertebrate Hox genes are clustered. This organization has a functional relevance, as the transcription of each gene in time and space depends upon its relative position within the gene cluster. Hox clusters display a… read more here.
Keywords: hox clusters; one several; mammalian hox; hox ... See more keywords
Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4622-0
Abstract: BackgroundHigh HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be… read more here.
Keywords: normal oral; potentially malignant; hox; hox pbx ... See more keywords
Aerobic efficiency is associated with the improvement in maximal power output during acute hyperoxia
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13119
Abstract: This study investigated the relationship between aerobic efficiency during cycling exercise and the increase in physical performance with acute hyperoxic exposure (FiO2 ~31%) (HOX) and also tested the hypothesis that fat oxidation could be increased… read more here.
Keywords: power output; maximal power; power; hox ... See more keywords