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   Articles with "hox" as a keyword



Downstream of the HOX genes: Explaining conflicting tumour suppressor and oncogenic functions in cancer

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recommendations! Published in 2022 at "International Journal of Cancer"

DOI: 10.1002/ijc.33949

Abstract: The HOX genes are a highly conserved group of transcription factors that have key roles in early development, but which are also highly expressed in most cancers. Many studies have found strong associative relationships between… read more here.

Keywords: tumour suppressor; hox genes; cancer; hox ... See more keywords

Noncoding RNAs within the HOX gene network in tumor pathogenesis and progression

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recommendations! Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.27036

Abstract: HOX genes are involved with normal development, cell identity, cell differentiation, cell metabolism, apoptosis, autophagy as well as with diseases such as tumor pathogenesis and progression. In particular, the genes belonging to HOX paralogous 13… read more here.

Keywords: tumor pathogenesis; progression; hox; pathogenesis progression ... See more keywords
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In silico analysis of HOX-associated transcription factors as potential regulators of oral cancer.

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recommendations! Published in 2021 at "Oral surgery, oral medicine, oral pathology and oral radiology"

DOI: 10.1016/j.oooo.2021.01.002

Abstract: OBJECTIVE The objective of this study was identification of the transcription factor binding sites (TFBS) in the promoter of HOX genes and elucidation of the comprehensive interaction of transcription factors (TFs)/genes with HOX. METHODOLOGY Promoter… read more here.

Keywords: transcription; silico analysis; hox; gene ... See more keywords
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Regulation of Hox and ParaHox Genes by Perfluorochemicals in Mouse Liver.

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recommendations! Published in 2020 at "Toxicology"

DOI: 10.1016/j.tox.2020.152521

Abstract: Homeobox (Hox) genes encode homeodomain proteins, which play important roles in the development and morphological diversification of organisms including plants and animals. Perfluorinated chemicals (PFCs), which are well recognized industrial pollutants and universally detected in… read more here.

Keywords: mouse livers; null mouse; hox; mrna expression ... See more keywords

The cis-regulatory logic underlying abdominal Hox-mediated repression versus activation of regulatory elements in Drosophila.

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recommendations! Published in 2019 at "Developmental biology"

DOI: 10.1016/j.ydbio.2018.11.006

Abstract: During development diverse transcription factor inputs are integrated by cis-regulatory modules (CRMs) to yield cell-specific gene expression. Defining how CRMs recruit the appropriate combinations of factors to either activate or repress gene expression remains a… read more here.

Keywords: transcription; hox; cis regulatory; activation ... See more keywords

Breaking constraint of mammalian axial formulae

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recommendations! Published in 2022 at "Nature Communications"

DOI: 10.1038/s41467-021-27335-z

Abstract: The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). The genetic mechanism(s) underlying this constraint however remain ill-defined. Here,… read more here.

Keywords: hox; axial formulae; vertebral column; constraint ... See more keywords

HOX gene expression in the developing human spine

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54187-0

Abstract: Positional coding along the anterior-posterior axis is regulated by HOX genes, whose 3’ to 5’ expression correlates with location along this axis. The precise utilisation of HOX genes in different human cell types is not… read more here.

Keywords: gene expression; hox; code; hox gene ... See more keywords

Selective interactions between diverse STEs organize the ANT-C Hox cluster

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recommendations! Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-33588-4

Abstract: The three-dimensional organization of the eukaryotic genome is important for its structure and function. Recent studies indicate that hierarchies of chromatin loops underlie important aspects of both genomic organization and gene regulation. Looping between insulator… read more here.

Keywords: chromatin; hox; insulator; gene ... See more keywords

Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster

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recommendations! Published in 2020 at "Communications Biology"

DOI: 10.1038/s42003-020-01456-5

Abstract: Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development. Post-translational modifications of histones contribute to transcriptional regulation. Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27… read more here.

Keywords: transcription; posterior hox; hox; lysine demethylase ... See more keywords

The constrained architecture of mammalian Hox gene clusters

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1904602116

Abstract: Significance Vertebrate Hox genes are clustered. This organization has a functional relevance, as the transcription of each gene in time and space depends upon its relative position within the gene cluster. Hox clusters display a… read more here.

Keywords: hox clusters; one several; mammalian hox; hox ... See more keywords

The Hox protein Antennapedia orchestrates Drosophila adult flight muscle development

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recommendations! Published in 2024 at "Science Advances"

DOI: 10.1126/sciadv.adr2261

Abstract: Muscle development and diversity require a large number of spatially and temporally regulated events controlled by transcription factors (TFs). Drosophila has long stood as a model to study myogenesis due to the highly conserved key… read more here.

Keywords: muscle; hox; muscle development; flight muscle ... See more keywords