Downstream of the HOX genes: Explaining conflicting tumour suppressor and oncogenic functions in cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.33949
Abstract: The HOX genes are a highly conserved group of transcription factors that have key roles in early development, but which are also highly expressed in most cancers. Many studies have found strong associative relationships between… read more here.
Keywords: tumour suppressor; hox genes; cancer; hox ... See more keywords
Analysis of Blood Subsets Deriving from Neonatal Cord Blood and Adult Blood, Focusing on the Developmental Age of Hematopoietic Stem Cells and Natural Killer Cells
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS Translational Medicine"
DOI: 10.1002/sctm.12555
Abstract: 6 Introduction Although it is known that fetal hematopoiesis and development of lymphocyte subsets, such as natural killer (NK) cells occur in distinct waves, resulting in a restricted set of hematopoietic functions, it remains unclear… read more here.
Keywords: hox genes; cord blood; developmental age; blood ... See more keywords
An exciting period of Drosophila developmental biology: Of imaginal discs, clones, compartments, parasegments and homeotic genes".
Sign Up to like & getrecommendations! Published in 2022 at "Developmental biology"
DOI: 10.1016/j.ydbio.2022.01.008
Abstract: In this review we recall a number of important discoveries that took place in Drosophila during seventies and eighties of the last century. The development of cell lineage methods and of powerful modifications of same,… read more here.
Keywords: developmental biology; body; drosophila; biology ... See more keywords
Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81472-5
Abstract: Hox genes are early determinants of cell identity along the anterior–posterior body axis across bilaterians. Several late non-homeotic functions of Hox genes have emerged in a variety of processes involved in organogenesis in several organisms,… read more here.
Keywords: gal4; hox genes; group; pseudo tumors ... See more keywords
Hox genes collaborate with helix-loop-helix factor Grainyhead to promote neuroblast apoptosis along the anterior-posterior axis of the Drosophila larval central nervous system.
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac101
Abstract: Hox genes code for a family of a homeodomain (HD) containing transcription factors that use TALE-HD containing factors Pbx/Exd and Meis/Hth to specify the development of the anterior-posterior (AP) axis of an organism. However, the… read more here.
Keywords: anterior posterior; apoptosis; central nervous; posterior axis ... See more keywords
Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of anatomy"
DOI: 10.1111/joa.13580
Abstract: A series of elegant embryo transfer experiments in the 1950s demonstrated that the uterine environment could alter vertebral patterning in inbred mouse strains. In the intervening decades, attention has tended to focus on the technical… read more here.
Keywords: hox genes; genes sex; sex steroids; sex ... See more keywords
Altered expression of 3´paralogus HOX A-D clusters in endometriosis disease: A case-control study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Reproductive Biomedicine"
DOI: 10.29252/ijrm.16.9.549
Abstract: Background: Endometriosis is a prevalent gynecological disease, with limited known etiology and more researches are required to identify its etiology. In this manner, there is no evidence for expression and function of 3´HOX genes in… read more here.
Keywords: endometriosis; hox genes; etiology; control ... See more keywords
Anterior Hox Genes and the Process of Cephalization
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.718175
Abstract: During evolution, bilateral animals have experienced a progressive process of cephalization with the anterior concentration of nervous tissue, sensory organs and the appearance of dedicated feeding structures surrounding the mouth. Cephalization has been achieved by… read more here.
Keywords: cephalization; hox genes; process cephalization; cephalization anterior ... See more keywords
Roles of Drosophila Hox Genes in the Assembly of Neuromuscular Networks and Behavior
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.786993
Abstract: Hox genes have been known for specifying the anterior-posterior axis (AP) in bilaterian body plans. Studies in vertebrates have shown their importance in developing region-specific neural circuitry and diversifying motor neuron pools. In Drosophila, they… read more here.
Keywords: region specific; drosophila hox; genes assembly; neuromuscular networks ... See more keywords
Roles of the HOX Proteins in Cancer Invasion and Metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers13010010
Abstract: Simple Summary Cancer is the second leading cause of death worldwide, right after cardiovascular diseases, and the invasion and metastatization correspond to the foremost cause of cancer-related deaths. Here, we reviewed the state of the… read more here.
Keywords: cancer; invasion metastasis; invasion; hox genes ... See more keywords
Functional analysis of HOXA10 and HOXB4 in human medulloblastoma cell lines.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of oncology"
DOI: 10.3892/ijo.2017.4151
Abstract: Medulloblastoma (MB) is a malignant childhood brain tumor which at molecular level is classified into at least four major subtypes: WNT, SHH, group C and group D differing in response to treatment. Previous studies have associated changes… read more here.
Keywords: hox genes; cell lines; medulloblastoma; migration ... See more keywords