HOX/PBX Inhibition Attenuates Tsc2-Null Cell Viability and Lung Metastasis in Lymphangioleiomyomatosis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732717
Abstract: Lymphangioleiomyomatosis (LAM) is a rare lung disease that exclusively affects premenopausal women. LAM is caused by infiltration of metastasizing atypical smooth muscle-like cells into the lungs leading to progressive respiratory failure. Though the origin of… read more here.
Keywords: lam; cell; hox pbx; physiology ... See more keywords
Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4622-0
Abstract: BackgroundHigh HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be… read more here.
Keywords: normal oral; potentially malignant; hox; hox pbx ... See more keywords
Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs
Sign Up to like & getrecommendations! Published in 2017 at "eNeuro"
DOI: 10.1523/eneuro.0404-17.2017
Abstract: Abstract Vital motor functions, such as respiration and locomotion, rely on the ability of spinal motor neurons (MNs) to acquire stereotypical positions in the ventral spinal cord and to project with high precision to their… read more here.
Keywords: transcriptional programs; connectivity; hox pbx; motor ... See more keywords
Targeting HOX/PBX dimers in cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15971
Abstract: The HOX and PBX gene families encode transcription factors that have key roles in establishing the identity of cells and tissues in early development. Over the last 20 years it has become apparent that they… read more here.
Keywords: pbx; pbx dimers; dimers cancer; hox pbx ... See more keywords