HOXA cluster antisense RNA 2 elevates KIAA1522 expression through microRNA‐520d‐3p and insulin like growth factor 2 mRNA binding protein 3 to promote the growth of vascular smooth muscle cells in thoracic aortic aneurysm
Sign Up to like & getrecommendations! Published in 2022 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13968
Abstract: Recently, long non‐coding RNAs (lncRNAs) have been revealed to mediate smooth muscle dysfunction in thoracic aortic aneurysm (TAA). LncRNA HOXA‐AS2 has been proposed to engage in the regulation of diverse diseases. However, its function in… read more here.
Keywords: hoxa; growth; thoracic aortic; aortic aneurysm ... See more keywords
Long noncoding RNA HOTTIP cooperates with CCCTC-binding factor to coordinate HOXA gene expression.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.173
Abstract: The spatiotemporal control of HOX gene expression is dependent on positional identity and often correlated to their genomic location within each loci. Maintenance of HOX expression patterns is under complex transcriptional and epigenetic regulation, which… read more here.
Keywords: ccctc binding; gene expression; hoxa; hottip ... See more keywords
Contribution of CTCF binding to transcriptional activity at the HOXA locus in NPM1-mutant AML cells
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0856-3
Abstract: Transcriptional regulation of the HOXA genes is thought to involve CTCF-mediated chromatin loops and the opposing actions of the COMPASS and Polycomb epigenetic complexes. We investigated the role of these mechanisms at the HOXA cluster… read more here.
Keywords: npm1 mutant; hoxa; ctcf binding; hoxa locus ... See more keywords
LncRNA HOXA-AS2 promotes the progression of prostate cancer via targeting miR-509-3p/PBX3 axis
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DOI: 10.1042/bsr20193287
Abstract: Abstract Long non-coding RNAs (lncRNAs) act as crucial modulators during the development of diverse cancers. Although various types of lncRNAs in prostate cancer (PCa) have been explored, quantities of lncRNAs still wait to be exploited.… read more here.
Keywords: expression; hoxa as2; mir 509; pbx3 ... See more keywords
HOXA Amplification Defines a Genetically Distinct Subset of Angiosarcomas
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DOI: 10.3390/biom12081124
Abstract: Angiosarcoma is a rare, devastating malignancy with few curative options for disseminated disease. We analyzed a recently published genomic data set of 48 angiosarcomas and noticed recurrent amplifications of HOXA cluster genes in 33% of… read more here.
Keywords: hoxa; amplification defines; hoxa amplification; defines genetically ... See more keywords