HOXA5 inhibits tumor growth of gastric cancer under the regulation of microRNA-196a.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.09.051
Abstract: Homeobox A5 (HOXA5) is a member of the HOX protein family which were implicated in serval critical process and was cancer-specific dysregulated in human cancers. However, its expression and function in human gastric cancer (GC)… read more here.
Keywords: gastric cancer; tumor growth; hoxa5; tumor ... See more keywords
HOXA5 overexpression promotes osteosarcoma cell apoptosis through the p53 and p38α MAPK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.11.081
Abstract: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Aberrant expression of HOXA5 results in various diseases, including cancers. However, the specific function and molecular mechanism of HOXA5 in osteosarcoma is not… read more here.
Keywords: p38 mapk; hoxa5; cell apoptosis; hoxa5 overexpression ... See more keywords
The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2021.111366
Abstract: The phenotypic change of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic form is a key player in atherogenic processes. Homeobox A5 (HOXA5), a transcription factor of the homeobox gene family, has… read more here.
Keywords: hoxa5; hoxa5 carotid; vascular smooth; carotid ... See more keywords
Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1924545
Abstract: Aldo-Keto Reductase Family 1 Member B10 (AKR1B10) and Homeobox A5 (HOXA5) are both down-regulated in adrenocortical carcinoma (ACC), and HOXA5 is predicted to bind to the promoter of AKR1B10. We aimed to investigate whether HOXA5… read more here.
Keywords: nci h295r; hoxa5; akr1b10; apoptosis ... See more keywords
Hoxa5 alleviates obesity‐induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14600
Abstract: Obesity‐induced chronic inflammation is associated with endoplasmic reticulum stress (ERS) in adipocytes and changes in both the number and phenotype of adipose tissue macrophages (ATMs). In addition, ERS enhances macrophage activation. So far, the function… read more here.
Keywords: chronic inflammation; obesity; hoxa5; adipose tissue ... See more keywords
Abstract 4467: The role of HOXA5 in the malignant progression of engineered isogenic MCF10A sublines harboring common breast cancer mutations
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4467
Abstract: Background and Aims: HOXA5 behaves as a tumor suppressor gene in breast cancer and regulates E-cadherin, CD24, progesterone receptor and p53. Retinoic acid activates transcription of HOXA5 by binding to RAR elements in the HOXA5… read more here.
Keywords: hoxa5; cancer; p53; cell ... See more keywords
HINT1 (Histidine Triad Nucleotide-Binding Protein 1) Attenuates Cardiac Hypertrophy Via Suppressing HOXA5 (Homeobox A5) Expression
Sign Up to like & getrecommendations! Published in 2021 at "Circulation"
DOI: 10.1161/circulationaha.120.051094
Abstract: Supplemental Digital Content is available in the text. Background: Cardiac hypertrophy is an important prepathology of, and will ultimately lead to, heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. This study… read more here.
Keywords: expression; hypertrophy; hoxa5; cardiac hypertrophy ... See more keywords
Knockdown of MPP8 suppresses cell proliferation via regulation of HOXA5 in non-small cell lung cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2018.64.1.6
Abstract: M-phase phosphoprotein 8 (MPP8) is reported to be closely implicated in cancer initiation and progression. In addition, the homeobox gene HOXA5 has been shown to play critical roles in hematopoiesis, embryogenesis, and tumorigenesis. Nevertheless, the… read more here.
Keywords: mpp8; cell; hoxa5; lung cancer ... See more keywords
MiR-301b-3p Promotes the Occurrence and Development of Breast Cancer Cells via Targeting HOXA5.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2021038215
Abstract: It has been reported that microRNA (miRNA) is an important regulator in various cancers. In this study, it was found by analyzing The Cancer Genome Atlas (TCGA) and bioinformatics database that miR-301b-3p was highly expressed… read more here.
Keywords: hoxa5; cancer cells; cancer; breast cancer ... See more keywords
microRNA-26a-5p Promotes Proliferation and Migration of Osteosarcoma Cells by Targeting HOXA5 in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s232100
Abstract: Background Osteosarcoma is the most common primary malignant tumor of bone. However, the underlying pathogenic mechanisms are still unclear. miR-26a was an endogenous non-coding small RNAs that have been showed to play a critical role… read more here.
Keywords: hoxa5; osteosarcoma cells; osteosarcoma; mir 26a ... See more keywords
Assessment of Expression of Homeobox A5 in Endometrial Cancer on the mRNA and Protein Level
Sign Up to like & getrecommendations! Published in 2019 at "Current Pharmaceutical Biotechnology"
DOI: 10.2174/1389201021666191227121627
Abstract: Background Endometrial cancer is one of the most common gynecological cancer in the developed countries and occurs mainly in postmenopausal women. Angiogenesis is important for cancer formation as it provides nutrients for growing tumor mass.… read more here.
Keywords: mrna protein; hoxa5; endometrial cancer; expression ... See more keywords