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   Articles with "hoxa9" as a keyword



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HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

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recommendations! Published in 2018 at "Cancer cell"

DOI: 10.1016/j.ccell.2018.08.018

Abstract: Aberrant expression of HOXA9 is a prominent feature of acute leukemia driven by diverse oncogenes. Here we show that HOXA9 overexpression in myeloid and B progenitor cells leads to significant enhancer reorganizations with prominent emergence… read more here.

Keywords: novo enhancers; leukemogenesis; hoxa9 reprograms; hoxa9 ... See more keywords
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MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells

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recommendations! Published in 2019 at "Leukemia"

DOI: 10.1038/s41375-019-0651-1

Abstract: MicroRNAs (miRNAs) are commonly deregulated in acute myeloid leukemia (AML), affecting critical genes not only through direct targeting, but also through modulation of downstream effectors. Homeobox (Hox) genes balance self-renewal, proliferation, cell death, and differentiation… read more here.

Keywords: hoxa9 meis1; program; hoxa9; mir 708 ... See more keywords
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Long non-coding RNA PCED1B-AS1 promotes the proliferation of colorectal adenocarcinoma through regulating the miR-633/HOXA9 axis

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2037225

Abstract: ABSTRACT Long non-coding RNA (lncRNA) PCED1B-AS1 was shown to play essential roles in human cancers, while its function in colorectal adenocarcinoma remains unclear. This study was carried out to investigate the function of PCED1B-AS1 in… read more here.

Keywords: colorectal adenocarcinoma; pced1b as1; hoxa9; mir 633 ... See more keywords
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HOXA9 mediates and marks premalignant compartment size expansion in colonic adenomas.

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recommendations! Published in 2019 at "Carcinogenesis"

DOI: 10.1093/carcin/bgz038

Abstract: The transformation of normal colonic epithelium to colorectal cancer (CRC) involves a relatively ordered progression, and understanding the molecular alterations involved may aid rational design of strategies aimed at preventing or counteracting disease. Homeobox A9… read more here.

Keywords: expression; growth; hoxa9; compartment size ... See more keywords
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Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance

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recommendations! Published in 2022 at "Open Biology"

DOI: 10.1098/rsob.220172

Abstract: HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukaemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different… read more here.

Keywords: transgenic zebrafish; acute myeloid; hoxa9; myeloid leukaemia ... See more keywords
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Meis1 supports leukemogenesis through stimulation of ribosomal biogenesis and Myc

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recommendations! Published in 2022 at "Haematologica"

DOI: 10.1101/2022.02.03.478956

Abstract: The homeobox transcription factors HoxA9 and Meis1 are causally involved in the etiology of acute myeloid leukemia. While HoxA9 immortalizes cells, cooperation with Meis1 is necessary to induce malignancy. Here, we apply degron techniques to… read more here.

Keywords: myc; stimulation; hoxa9; ribosomal biogenesis ... See more keywords
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miR-652 Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting HOXA9 and Regulating the PI3K/Akt Signaling Pathway

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recommendations! Published in 2022 at "Journal of Oncology"

DOI: 10.1155/2022/4809312

Abstract: Objective The aim of this study was to investigate the abnormal expression of miR-652 in osteosarcoma and its related mechanism. Materials and Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of… read more here.

Keywords: mir 652; hoxa9; expression; proliferation ... See more keywords
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Abstract B015: HOXA9 promotes enzalutamide resistance in RB-p53 deficient prostate cancer

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.prca2023-b015

Abstract: Introduction: Castration resistant prostate cancer (CRPC) cells can acquire resistance to the androgen receptor (AR) inhibitor enzalutamide (EZ). These cells can switch lineages from an adenocarcinoma to a neuroendocrine (NE) cell type that proliferate independently… read more here.

Keywords: prostate cancer; resistance; hoxa9; dko cells ... See more keywords
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Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9.

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recommendations! Published in 2020 at "Blood"

DOI: 10.1182/blood.2019004586

Abstract: The pseudokinase Trib1 functions as a myeloid oncogene that recruits the E3 ubiquitin ligase COP1 to C/EBPa and interacts with MEK1 to enhance ERK phosphorylation. Close genetic effect of Trib1 on Hoxa9 has been observed… read more here.

Keywords: trib1 promotes; myeloid leukemia; hoxa9; trib1 ... See more keywords
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HoxA9 transforms murine myeloid cells by a feedback loop driving expression of key oncogenes and cell cycle control genes.

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recommendations! Published in 2018 at "Blood advances"

DOI: 10.1182/bloodadvances.2018025866

Abstract: Ectopic expression of the oncogenic transcription factor HoxA9 is a major cause of acute myeloid leukemia (AML). Here, we demonstrate that HoxA9 is a specific substrate of granule proteases. Protease knockout allowed the comprehensive determination… read more here.

Keywords: transcription; feedback loop; hoxa9; cell cycle ... See more keywords
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MiR-19b-3p promotes tumor progression of non-small cell lung cancer via downregulating HOXA9 and predicts poor prognosis in patients.

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recommendations! Published in 2022 at "Histology and histopathology"

DOI: 10.14670/hh-18-448

Abstract: MiR-19b-3p has been reported in several types of human cancer. Nevertheless, the expression profile and biological functions of miR-19b-3p remain unclear in non-small cell lung cancer (NSCLC). The expression level of miR-19b-3p was evaluated in… read more here.

Keywords: non small; small cell; mir 19b; hoxa9 ... See more keywords