HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia
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DOI: 10.1182/blood-2024-199171
Abstract: Nucleoporin 98 (NUP98) fusion oncoproteins are implicated in various types of leukemia, particularly high-risk childhood leukemias. These NUP98 fusion-driven leukemias often exhibit unique aberrant HOX gene signatures that play critical roles in transforming hematopoietic stem… read more here.
Keywords: leukemic transcription; leukemia; hoxblinc; nup98 fusion ... See more keywords