HP1α is highly expressed in glioma cells and facilitates cell proliferation and survival.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.056
Abstract: Epigenetic alteration plays critical roles in gliomagenesis by regulating gene expression through modifications of Histones and DNA. Trimethylation of H3K9, an essential repressed transcription mark, and one of its methyltransferase, SUV39H1, are implicated in glioma… read more here.
Keywords: glioma; cell proliferation; hp1; h3k9me3 ... See more keywords
Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0104-9
Abstract: Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide… read more here.
Keywords: protein; heterochromatin; methylation; hp1 ... See more keywords
HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1159
Abstract: Abstract Nucleoli are nuclear compartments regulating ribosome biogenesis and cell growth. In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes are spatially separated from pericentromeric satellite repeat sequences packaged in largely repressed constitutive… read more here.
Keywords: heterochromatin; hp1; function; pch ... See more keywords
Molecular interactions underlying the phase separation of HP1α: role of phosphorylation, ligand and nucleic acid binding
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1194
Abstract: Heterochromatin protein 1α (HP1α) is a crucial component for the proper maintenance of chromatin structure and function. It has been proposed that HP1α functions through liquid-liquid phase separation (LLPS), which allows it to sequester and… read more here.
Keywords: hp1; phase; phase separation; nucleic acid ... See more keywords
HP1 maintains protein stability of H3K9 methyltransferases and demethylases
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202153581
Abstract: Di‐ or tri‐methylated H3K9 (H3K9me2/3) is an epigenetic mark of heterochromatin. Heterochromatin protein 1 (HP1) specifically recognizes H3K9me2/3, contributing to transcriptional suppression and spread of H3K9me2/3. Here, we demonstrate another role of HP1 in heterochromatin… read more here.
Keywords: protein stability; hp1; stability h3k9;