HP1 proteins safeguard embryonic stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/d41586-018-05188-9
Abstract: A complex that includes the protein HP1 binds to specific regulatory DNA sequences to promote local compaction of genomic regions and inhibit associated genes that drive differentiation of specific cell lineages.A complex that includes the… read more here.
Keywords: hp1 proteins; proteins safeguard; embryonic stem; stem cells ... See more keywords
HP1 proteins regulate nucleolar structure and function by secluding pericentromeric constitutive heterochromatin
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1159
Abstract: Abstract Nucleoli are nuclear compartments regulating ribosome biogenesis and cell growth. In embryonic stem cells (ESCs), nucleoli containing transcriptionally active ribosomal genes are spatially separated from pericentromeric satellite repeat sequences packaged in largely repressed constitutive… read more here.
Keywords: heterochromatin; hp1; function; pch ... See more keywords