The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time
Sign Up to like & getrecommendations! Published in 2020 at "BioEssays"
DOI: 10.1002/bies.202000007
Abstract: With aging, incidence of severe stress‐related diseases increases. However, mechanisms, underlying individual vulnerability to stress and age‐related diseases are not clear. The goal of this review is to analyze finding from the recent literature on… read more here.
Keywords: stress; individual vulnerability; hpa axis;
Gonadal hormones modulate the HPA‐axis and the SNS in response to psychosocial stress
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24259
Abstract: Exposure to stress activates both the hypothalamus‐pituitary‐adrenal (HPA) axis and the sympathetic nervous system (SNS). A growing body of research points to the contribution of sex hormones (testosterone, estrogen, and progesterone), the end products of… read more here.
Keywords: psychosocial stress; hpa axis; reactivity; stress ... See more keywords
Long-Term Effects of the Periconception Period on Embryo Epigenetic Profile and Phenotype: The Role of Stress and How This Effect Is Mediated.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-62414-3_7
Abstract: Stress represents an unavoidable aspect of human life, and pathologies associated with dysregulation of stress mechanisms - particularly psychiatric disorders - represent a significant global health problem. While it has long been observed that levels… read more here.
Keywords: periconception period; role stress; hpa axis; stress ... See more keywords
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
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DOI: 10.1007/s00213-017-4720-8
Abstract: RationaleSaikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties.ObjectivesThe present study was designed to investigate the anti-depressant-like effects and the potential mechanisms of SSD.MethodsBehavioural tests including… read more here.
Keywords: hippocampal neurogenesis; unpredictable chronic; chronic mild; hpa axis ... See more keywords
HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Women's Mental Health"
DOI: 10.1007/s00737-017-0716-y
Abstract: It is unclear whether women with a history of postpartum depression (PPD) have residual, abnormal hypothalamic-pituitary-adrenal (HPA) axis reactivity, as has been reported in major depression (MDD). Further unclear is whether the abnormalities in HPA… read more here.
Keywords: depression; axis reactivity; response; hpa axis ... See more keywords
Endocannabinoid hydrolase and cannabinoid receptor 1 are involved in the regulation of hypothalamus-pituitary-adrenal axis in type 2 diabetes
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DOI: 10.1007/s11011-018-0255-x
Abstract: Hypothalamus-pituitary-adrenal (HPA) axis, as the key moderator in energy metabolism, plays an important role in diabetes. The endogenous cannabinoid system (eCBs) involves in neuronal functions, and simultaneously cannabinoid receptors are almost expressed in all regions… read more here.
Keywords: receptor; cannabinoid receptor; type diabetes; hpa axis ... See more keywords
Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02470-2
Abstract: The stress response is multifactorial and enrolls circuitries to build a coordinated reaction, leading to behavioral, endocrine, and autonomic changes. These changes are mainly related to the hypothalamus-pituitary-adrenal (HPA) axis activation and the organism's integrity.… read more here.
Keywords: cus; stress; crf; hpa axis ... See more keywords
Insufficient glucocorticoid receptor signaling and flattened salivary cortisol profile are associated with metabolic and inflammatory indices in type 2 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01260-2
Abstract: Purpose Impaired negative feedback and hyperactivation of the hypothalamic–pituitary–adrenal (HPA) axis characterizes type 2 diabetes mellitus (T2DM). The glucocorticoid receptor (GR) is a key mediator of HPA axis negative feedback; however, its role in linking… read more here.
Keywords: cortisol; t2dm patients; hpa axis; salivary cortisol ... See more keywords
Central Neuroepigenetic Regulation of the Hypothalamic-Pituitary-Adrenal Axis.
Sign Up to like & getrecommendations! Published in 2018 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2018.04.006
Abstract: Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life… read more here.
Keywords: neuroepigenetic regulation; hpa axis; hypothalamic pituitary; pituitary adrenal ... See more keywords
HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women
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DOI: 10.1016/j.bbi.2020.11.027
Abstract: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been associated with altered immune function, but the underlying molecular mechanisms are unclear. Epigenetic processes, including DNA methylation, respond to the glucocorticoid end-products of the HPA axis (cortisol in humans)… read more here.
Keywords: chronically stressed; methylation; axis regulation; hpa axis ... See more keywords
Long-term effects of repeated maternal separation and ethanol intake on HPA axis responsiveness in adult rats
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DOI: 10.1016/j.brainres.2016.11.034
Abstract: It has been shown that early life manipulations produce behavioral, neural, and hormonal effects. The long term consequences of repeated maternal separation (RMS) plus cold stress and ethanol intake were evaluated during adolescence and adult… read more here.
Keywords: stress; ethanol intake; hpa axis; adult rats ... See more keywords