PKU mutation p.G46S prevents the stereospecific binding of l‐phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain
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DOI: 10.1002/2211-5463.12175
Abstract: Mammalian phenylalanine hydroxylase (PAH) has a potential allosteric regulatory binding site for l‐phenylalanine (l‐Phe), in addition to its catalytic site. This arrangement is supported by a crystal structure of a homodimeric truncated form of the… read more here.
Keywords: hpah; regulatory domain; phenylalanine; phenylalanine hydroxylase ... See more keywords