Cisplatin cyclodextrin complexes as potential free radical chemoradiosensitizers for enhanced cisplatin treatment of cancers: a quantum mechanical study
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Inclusion Phenomena and Macrocyclic Chemistry"
DOI: 10.1007/s10847-017-0760-2
Abstract: It has been shown in this study that {CisPt@[n]CD} complexes formed from the anti-cancer drug cisplatin (CisPt) and cyclodextrins ([n]CD) can be a source of Pt based free radicals such as (H3N)2PtCl· and (H3N)2Pt·· species… read more here.
Keywords: cispt; cyclodextrin; cisplatin; study ... See more keywords
Cholecalciferol complexation with hydroxypropyl-β-cyclodextrin (HPBCD) and its molecular dynamics simulation
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2064492
Abstract: Abstract The focus of the current study is to investigate cholecalciferol (vitamin D3) solubilization by hydroxypropyl-β-cyclodextrin (HPBCD) complexation through experimental and computational studies. Phase solubility diagram of vitamin D3 (completely insoluble in water) has an… read more here.
Keywords: hydroxypropyl cyclodextrin; cyclodextrin hpbcd; hpbcd; molecular dynamics ... See more keywords
Enhancement of Silymarin Anti-fibrotic Effects by Complexation With Hydroxypropyl (HPBCD) and Randomly Methylated (RAMEB) β-Cyclodextrins in a Mouse Model of Liver Fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00883
Abstract: Silymarin (Sy) shows limited water solubility and poor oral bioavailability. Water-soluble hydroxypropyl (HPBCD) and randomly methylated (RAMEB) β-cyclodextrins were designed to enhance anti-fibrotic efficiency of silymarin in CCl4-induced liver fibrosis in mice. Experimental fibrosis was… read more here.
Keywords: anti fibrotic; silymarin; liver fibrosis; rameb ... See more keywords
Effects of Hydroxypropyl-Beta-Cyclodextrin on Cultured Brain Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27227738
Abstract: The application of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) in the treatment of the rare cholesterol and lipid storage disorder Niemann–Pick disease type C opened new perspectives in the development of an efficient therapy. Even if the systemic administration… read more here.
Keywords: endothelial cells; hpbcd; brain; beta cyclodextrin ... See more keywords