High protein diet-induced metabolic changes are transcriptionally regulated via KLF15-dependent and independent pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.10.027
Abstract: High protein diet (HPD) is an affordable and positive approach in prevention and treatment of many diseases. It is believed that transcriptional regulation is responsible for adaptation after HPD feeding and Kruppel-like factor 15 (KLF15),… read more here.
Keywords: amino acid; diet induced; high protein; protein diet ... See more keywords
Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109617
Abstract: The liver plays central roles in coordinating different metabolic processes, such as the catabolism of amino acids. In this study, we identify a loss of tyrosine catabolism and a concomitant increase in serum tyrosine levels… read more here.
Keywords: loss tyrosine; tyrosine; hpd; liver cancer ... See more keywords
Development of a fluorescent probe for the detection of hPD-L1.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2020.06.009
Abstract: Interaction of human programmed death factor-1 (hPD-1) of T cells and one of its ligands hPD-L1 which is expressed on cancer cells suppresses effector T cell functions. Studies showed that the hPD-1/hPD-L1 pathway is associated… read more here.
Keywords: fluorescent probe; detection; detection hpd; hpd ... See more keywords
Glycan-Controlled Human PD-1 Variants Displaying Broad-Spectrum High Binding to PD-1 Ligands Potentiate T Cell.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00003
Abstract: Although therapeutic immunoglobulin G (IgG) antibodies that regulate the activity of immune checkpoints bring innovation to the field of immuno-oncology, they are still limited in their efficiency to infiltrate the tumor microenvironment due to their… read more here.
Keywords: hpd; high binding; glycan controlled; controlled human ... See more keywords
Synthesis of Trimetallic (HPd@M2Au8)3+ Superatoms (M = Ag, Cu) via Hydride-Mediated Regioselective Doping to (Pd@Au8)2+
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b00575
Abstract: We have recently reported that hydride (H–) doped superatom (HPd@Au8)+ protected by eight PPh3 ligands selectively grew into (HPd@Au10)3+ by the nucleophilic addition of two Au(I)Cl units. In the present study, (HPd@Au8)+ was successfully converted… read more here.
Keywords: m2au8 superatoms; hydride mediated; hpd m2au8; trimetallic hpd ... See more keywords
PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1822001116
Abstract: Significance PD-1 blockade is a cancer immunotherapy effective in various types of cancer. However, we observed rapid cancer progression, called hyperprogressive disease (HPD), in ∼10% of advanced gastric cancer patients treated with anti–PD-1 monoclonal antibody.… read more here.
Keywords: blockade; hpd; etreg cells; cancer ... See more keywords
Combining Enhancement of Inhibitory Signals and Blockade of Co-Stimulation to Modulate Human Anti-Pig Immune Responses
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation"
DOI: 10.1097/01.tp.0000543722.75155.57
Abstract: Introduction Transgenic expression of human modulatory molecules in pigs is a promising approach to prevent human anti-porcine immune responses and thus, an important step on the way to clinical xenotransplantation. We have previously shown that… read more here.
Keywords: stimulation; lea29y; inhibitory signals; l23 ... See more keywords
Hepatopancreatoduodenectomy for advanced biliary malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002067
Abstract: Abstract Background: Hepatopancreatoduodenectomy (HPD) has been considered the only curative treatment for metastatic cholangiocarcinoma and some locally advanced gallbladder cancers (GBCs). However, HPD has not yet been included in treatment guidelines as a standard surgical… read more here.
Keywords: hpd; advanced gbc; hepatopancreatoduodenectomy advanced; patients advanced ... See more keywords
Effects of different weight loss dietary interventions on body mass index and glucose and lipid metabolism in obese patients
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033254
Abstract: To investigate the effects of different weight loss interventions on body mass index (BMI) and glucose and lipid metabolism in obese patients. Obese patients (n = 135) admitted to our hospital between December 2020 and August 2022… read more here.
Keywords: hpd; group; crd 001; crd ... See more keywords
Whole genome duplication and transposable element proliferation drive genome expansion in Corydoradinae catfishes
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the Royal Society B: Biological Sciences"
DOI: 10.1098/rspb.2017.2732
Abstract: Genome size varies significantly across eukaryotic taxa and the largest changes are typically driven by macro-mutations such as whole genome duplications (WGDs) and proliferation of repetitive elements. These two processes may affect the evolutionary potential… read more here.
Keywords: transposable element; whole genome; size; hpd ... See more keywords
Hybrid Precoding for Mixture Use of Phase Shifters and Switches in mmWave Massive MIMO
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Transactions on Communications"
DOI: 10.1109/tcomm.2022.3173304
Abstract: A variable-phase-shifter (VPS) architecture with hybrid precoding for mixture use of phase shifters and switches, is proposed for millimeter wave massive multiple-input multiple-output communications. For the VPS architecture, a hybrid precoding design (HPD) scheme, called… read more here.
Keywords: hpd; hpd scheme; vps hpd; phase ... See more keywords