Strain-dependent neutralization reveals antigenic variation of human parechovirus 3
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DOI: 10.1038/s41598-017-12458-5
Abstract: Human parechovirus 3 (HPeV3), a member of the Picornavirus family, is frequently detected worldwide. However, the observed seropositivity rates for HPeV3 neutralizing antibodies (nAbs) vary from high in Japan to low in the Netherlands and… read more here.
Keywords: variation; neutralization; hpev3; strain ... See more keywords
A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody
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DOI: 10.1128/jvi.01597-18
Abstract: Human parechovirus 3 (HPeV3) is receiving increasing attention as a prevalent cause of sepsis-like symptoms in neonates, for which, despite the severity of disease, there are no effective treatments available. Structural and molecular insights into… read more here.
Keywords: resolution; microscopy; antibody; hpev3 ... See more keywords
Bioinformatics-based prediction of conformational epitopes for human parechovirus
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DOI: 10.1371/journal.pone.0247423
Abstract: Human parechoviruses (HPeVs) are human pathogens that usually cause diseases ranging from rash to neonatal sepsis in young children. HPeV1 and HPeV3 are the most frequently reported genotypes and their three-dimensional structures have been determined.… read more here.
Keywords: based prediction; hpev1 hpev3; bioinformatics based; hpev3 ... See more keywords