Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
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DOI: 10.1038/s41467-021-20998-8
Abstract: Poly-(ADP-ribose) polymerase 1 and 2 (PARP1 and PARP2) are key enzymes in the DNA damage response. Four different inhibitors (PARPi) are currently in the clinic for treatment of ovarian and breast cancer. Recently, histone PARylation… read more here.
Keywords: histone parylation; parylation; parylation factor; cancer ... See more keywords
HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histones
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DOI: 10.1038/s41467-021-21302-4
Abstract: Upon binding to DNA breaks, poly(ADP-ribose) polymerase 1 (PARP1) ADP-ribosylates itself and other factors to initiate DNA repair. Serine is the major residue for ADP-ribosylation upon DNA damage, which strictly depends on HPF1. Here, we… read more here.
Keywords: serine adp; adp ribosylation; parp1; hpf1 ... See more keywords