Genetic variants of G‐protein coupled receptors associated with pubertal disorders
Sign Up to like & getrecommendations! Published in 2023 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12515
Abstract: Abstract Background The human hypothalamic–pituitary‐gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G‐protein coupled receptors (GPCRs) encoded by KISS1R, TACR3, PROKR2, GNRHR, LHCGR, and FSHR. Methods Previous studies have… read more here.
Keywords: hpg axis; protein coupled; pubertal disorders; coupled receptors ... See more keywords
Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2017.02.013
Abstract: Both diethylstilbestrol (DES, an environmental estrogen) and flutamide (FLU, an anti-androgen) are found to impair spermatogenesis by disrupting hypothalamic-pituitary-gonadal (HPG) axis and altering androgen levels through different mechanisms/modes of action in fish with poorly understood… read more here.
Keywords: combination; apoptosis; des flu; hpg axis ... See more keywords
Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2016.09.099
Abstract: The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using in silico and in vivo assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ERα, ERβ, AR, GR)… read more here.
Keywords: silico vivo; reproductive interrenal; evidence; pcp ... See more keywords
Detection of endocrine disrupting chemicals and evidence of their effects on the HPG axis of the European anchovy Engraulis encrasicolus.
Sign Up to like & getrecommendations! Published in 2017 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2017.04.006
Abstract: Natural/synthetic Endocrine Disrupting Chemicals (EDCs) may display estrogenic activity and a lower potency than 17β-estradiol. Nonetheless, their concentrations and additive effects can affect the endocrine system and reproductive processes related to the Hypothalamic-Pituitary-Gonadal (HPG) axis.… read more here.
Keywords: anchovy engraulis; endocrine disrupting; anchovy; disrupting chemicals ... See more keywords
Arsenic-induced Autophagic Alterations and Mitochondrial Impairments in HPG-S Axis of Mature Male Mice Offspring (F1-generation): A persistent toxicity study.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.02.013
Abstract: Arsenic (As) has been implicated in causing reproductive toxicity, but the precise cellular pathway through which the As toxicity in mature F1- male mice hypothalamic-pituitary- gonadal- sperm (HPG-S) axis is induced has not well been… read more here.
Keywords: toxicity; male mice; dose dependent; mature male ... See more keywords
Widespread patterns of sexually dimorphic gene expression in an avian hypothalamic–pituitary–gonadal (HPG) axis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45125
Abstract: The hypothalamic-pituitary-gonadal (HPG) axis is a key biological system required for reproduction and associated sexual behaviors to occur. In the avian reproductive model of the rock dove (Columba livia), we characterized the transcript community of… read more here.
Keywords: pituitary gonadal; hypothalamic pituitary; hpg; expression ... See more keywords
Transcriptomic analyses of the HPG axis-related tissues reveals potential candidate genes and regulatory pathways associated with egg production in ducks
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-022-08483-y
Abstract: Background Egg production is one of the most important economic traits in the poultry industry. The hypothalamic-pituitary–gonadal (HPG) axis plays an essential role in regulating reproductive activities. However, the key genes and regulatory pathways within… read more here.
Keywords: egg production; related tissues; egg; candidate genes ... See more keywords
Pleomorphism of the HPG axis with NR0B1 gene mutation—a case report of longitudinal follow-up of a proband with central precocious puberty
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0762
Abstract: Abstract Objectives X-linked adrenal hypoplasia congenita (AHC) is characterized by adrenal insufficiency and hypogonadotropic hypogonadism. Herein, we report a rare case of X-linked AHC with central precocious puberty (CPP). Case presentation An 11-month-old male patient… read more here.
Keywords: precocious puberty; longitudinal follow; nr0b1 gene; case ... See more keywords
Pathological changes and oxidative stress of the HPG axis in hypothyroid rat.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-21-0095
Abstract: Hypothyroidism is a common endocrine disease caused by a deficiency of thyroid hormones, which could affect the hypothalamus-pituitary-gonadal (HPG) axis and cause additional severe fertility problems. However, the pathogenesis of abnormal reproductive capacity caused by… read more here.
Keywords: hpg axis; stress; hypothyroidism; oxidative stress ... See more keywords
Characterization of gene expression in the hypothalamo-pituitary-gonadal axis during the preovulatory surge in the turkey hen
Sign Up to like & getrecommendations! Published in 2019 at "Poultry Science"
DOI: 10.3382/ps/pez437
Abstract: A preovulatory surge (PS) of luteinizing hormone (LH) and progesterone triggers follicle ovulation, which is the first step of egg production and is orchestrated by the hypothalamo-pituitary-gonadal (HPG) axis. In the HPG axis, hypothalamic peptides,… read more here.
Keywords: hormone; gene expression; expression; hpg axis ... See more keywords
Ontogeny of Hypothalamus-Pituitary Gonadal Axis and Minipuberty: An Ongoing Debate?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2020.00187
Abstract: The fetal hypothalamus-pituitary gonadal (HPG) axis begins to function during mid-gestation but its activity decreases during late pregnancy due to the suppressive effects of placental estrogens. Placental hormones drop immediately after birth, FSH and LH… read more here.
Keywords: minipuberty; pituitary gonadal; axis; hypothalamus pituitary ... See more keywords