Genetic variants of G‐protein coupled receptors associated with pubertal disorders
Sign Up to like & getrecommendations! Published in 2023 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12515
Abstract: Abstract Background The human hypothalamic–pituitary‐gonadal (HPG) axis is the regulatory center for pubertal development. This axis involves six G‐protein coupled receptors (GPCRs) encoded by KISS1R, TACR3, PROKR2, GNRHR, LHCGR, and FSHR. Methods Previous studies have… read more here.
Keywords: hpg axis; protein coupled; pubertal disorders; coupled receptors ... See more keywords
Intracerebroventricular PROK2 infusion could increase the secretion of male reproductive hormones by stimulating the HPG axis
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology Reports"
DOI: 10.1007/s11033-024-09604-4
Abstract: Prokineticin 2 (PROK2), an important neuropeptide that plays a key role in the neuronal migration of gonadotropin-releasing hormone (GnRH) in the hypothalamus, is known to have regulatory effects on the gonads. In the present study,… read more here.
Keywords: hpg axis; prok2; infusion; prok2 infusion ... See more keywords
Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2017.02.013
Abstract: Both diethylstilbestrol (DES, an environmental estrogen) and flutamide (FLU, an anti-androgen) are found to impair spermatogenesis by disrupting hypothalamic-pituitary-gonadal (HPG) axis and altering androgen levels through different mechanisms/modes of action in fish with poorly understood… read more here.
Keywords: combination; apoptosis; des flu; hpg axis ... See more keywords
Pentachlorophenol affected both reproductive and interrenal systems: In silico and in vivo evidence.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2016.09.099
Abstract: The present study investigated the effects on reproductive and interrenal system by pentachlorophenol (PCP) using in silico and in vivo assays. Molecular docking results indicated interacting potency of PCP with steroid receptors (ERα, ERβ, AR, GR)… read more here.
Keywords: silico vivo; reproductive interrenal; evidence; pcp ... See more keywords
Detection of endocrine disrupting chemicals and evidence of their effects on the HPG axis of the European anchovy Engraulis encrasicolus.
Sign Up to like & getrecommendations! Published in 2017 at "Marine environmental research"
DOI: 10.1016/j.marenvres.2017.04.006
Abstract: Natural/synthetic Endocrine Disrupting Chemicals (EDCs) may display estrogenic activity and a lower potency than 17β-estradiol. Nonetheless, their concentrations and additive effects can affect the endocrine system and reproductive processes related to the Hypothalamic-Pituitary-Gonadal (HPG) axis.… read more here.
Keywords: anchovy engraulis; endocrine disrupting; anchovy; disrupting chemicals ... See more keywords
Arsenic-induced Autophagic Alterations and Mitochondrial Impairments in HPG-S Axis of Mature Male Mice Offspring (F1-generation): A persistent toxicity study.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.02.013
Abstract: Arsenic (As) has been implicated in causing reproductive toxicity, but the precise cellular pathway through which the As toxicity in mature F1- male mice hypothalamic-pituitary- gonadal- sperm (HPG-S) axis is induced has not well been… read more here.
Keywords: toxicity; male mice; dose dependent; mature male ... See more keywords
Longer duration of intact hypothalamic–pituitary–gonadal (HPG) axis buffers the adverse impact of late-life frailty in male dogs
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20700-8
Abstract: Research on physical frailty has focused primarily on understanding the factors that lead to frailty development and on discovering strategies that might prevent or postpone the onset of frailty. In contrast, relatively little attention has… read more here.
Keywords: life frailty; late life; hpg axis; life ... See more keywords
Widespread patterns of sexually dimorphic gene expression in an avian hypothalamic–pituitary–gonadal (HPG) axis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45125
Abstract: The hypothalamic-pituitary-gonadal (HPG) axis is a key biological system required for reproduction and associated sexual behaviors to occur. In the avian reproductive model of the rock dove (Columba livia), we characterized the transcript community of… read more here.
Keywords: pituitary gonadal; hypothalamic pituitary; hpg; expression ... See more keywords
Transcriptomic analyses of the HPG axis-related tissues reveals potential candidate genes and regulatory pathways associated with egg production in ducks
Sign Up to like & getrecommendations! Published in 2022 at "BMC Genomics"
DOI: 10.1186/s12864-022-08483-y
Abstract: Background Egg production is one of the most important economic traits in the poultry industry. The hypothalamic-pituitary–gonadal (HPG) axis plays an essential role in regulating reproductive activities. However, the key genes and regulatory pathways within… read more here.
Keywords: egg production; related tissues; egg; candidate genes ... See more keywords
The dynamic landscape of chromatin accessibility and active regulatory elements in the mediobasal hypothalamus influences the seasonal activation of the reproductive axis in the male quail under long light exposure
Sign Up to like & getrecommendations! Published in 2024 at "BMC Genomics"
DOI: 10.1186/s12864-024-10097-5
Abstract: Background In cold and temperate zones, seasonal reproduction plays a crucial role in the survival and reproductive success of species. The photoperiod influences reproductive processes in seasonal breeders through the hypothalamic-pituitary-gonadal (HPG) axis, in which… read more here.
Keywords: hpg axis; activation; axis; accessibility ... See more keywords
Pleomorphism of the HPG axis with NR0B1 gene mutation—a case report of longitudinal follow-up of a proband with central precocious puberty
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Endocrinology and Metabolism"
DOI: 10.1515/jpem-2021-0762
Abstract: Abstract Objectives X-linked adrenal hypoplasia congenita (AHC) is characterized by adrenal insufficiency and hypogonadotropic hypogonadism. Herein, we report a rare case of X-linked AHC with central precocious puberty (CPP). Case presentation An 11-month-old male patient… read more here.
Keywords: precocious puberty; longitudinal follow; nr0b1 gene; case ... See more keywords