Orally Efficacious Broad-Spectrum Allosteric Inhibitor of Paramyxovirus Polymerase
Sign Up to like & getrecommendations! Published in 2020 at "Nature microbiology"
DOI: 10.1038/s41564-020-0752-7
Abstract: Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a… read more here.
Keywords: spectrum allosteric; hpiv3; polymerase; viral polymerase ... See more keywords
Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3
Sign Up to like & getrecommendations! Published in 2019 at "Viruses"
DOI: 10.3390/v11050438
Abstract: The matrix (M) proteins of paramyxoviruses bind to the nucleocapsids and cytoplasmic tails of glycoproteins, thus mediating the assembly and budding of virions. We first determined the budding characterization of the HPIV3 Fusion (F) protein… read more here.
Keywords: human parainfluenza; virus type; hpiv3; parainfluenza virus ... See more keywords
Genetic Analysis of HPIV3 That Emerged during the SARS-CoV-2 Pandemic in Gwangju, South Korea
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071446
Abstract: Community mitigation measures taken owing to the COVID-19 pandemic have caused a decrease in the number of respiratory viruses, including the human parainfluenza virus type 3 (HPIV3), and a delay in their occurrence. HPIV3 was… read more here.
Keywords: hpiv3 emerged; hpiv3; gwangju; genetic analysis ... See more keywords