Abstract 7009: Discovery of UBX-306 as a potent, selective, and orally bioavailable HPK1 degrader
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DOI: 10.1158/1538-7445.am2025-7009
Abstract: Hematopoietic progenitor kinase 1 (HPK1), part of the MAP4K family, is a serine/threonine kinase critical for modulating immune cell signaling and function. HPK1 is predominantly expressed in hematopoietic cells, where it acts as a negative… read more here.
Keywords: degradation; ubx 306; hpk1 degrader; cell ... See more keywords