Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy.
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DOI: 10.1021/acs.jmedchem.2c01551
Abstract: Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell activation, and targeting HPK1 is considered a promising strategy for improving responses to antitumor immune therapies. The biggest challenge of HPK1 inhibitor design is… read more here.
Keywords: hpk1 inhibitors; based hpk1; discovery macrocycle; macrocycle based ... See more keywords
Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
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DOI: 10.1021/acsmedchemlett.2c00238
Abstract: In spite of the great success of immune checkpoint inhibitors in immune-oncology therapy, an urgent need still exists to identify alternative approaches to broaden the scope of therapeutic coverage. Hematopoietic progenitor kinase 1 (HPK1), also… read more here.
Keywords: derivatives hpk1; discovery pyrazolopyridine; chemistry; pyrazolopyridine derivatives ... See more keywords