Biotinylated HPMA Centered Polymeric Nanoparticles for Bortezomib Delivery.
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DOI: 10.1016/j.ijpharm.2020.119173
Abstract: Bortezomib (BTZ) is a proteasome inhibitor as approved by US FDA for the treatment of multiple myeloma. It exhibits significant anti-cancer properties including against solid tumors; but lacks aqueous solubility, chemical stability which hinders its… read more here.
Keywords: polymeric nanoparticles; biotinylated hpma; delivery; hpma ... See more keywords
Poly(HPMA)-based copolymers with biodegradable side chains able to self assemble into nanoparticles
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DOI: 10.1039/c7ra11179g
Abstract: N-(2-Hydroxypropyl)methacrylamide (HPMA) is a water soluble monomer used in the synthesis of biocompatible and non-immunogenic polymers. In particular, poly(HPMA) can be exploited to sterically stabilize nanoparticles (NPs) suitable for the delivery of lipophilic therapeutics without… read more here.
Keywords: side chains; poly hpma; hpma; self ... See more keywords
Design and fabrication of poly(HPMA)–6-mercaptopurine conjugates and their in vitro anticancer effect
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj04039g
Abstract: In this work, a new kind of polymer system based on poly(N-(2-hydroxypropyl)methacrylamide) (poly(HPMA)) for transporting the anticancer drug 6-mercaptopurine (6MP) was successfully prepared. The vinyl groups were grafted onto the polymer chains via the reaction… read more here.
Keywords: mercaptopurine; poly hpma; hpma; effect ... See more keywords