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   Articles with "hpma copolymers" as a keyword



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Glycan-decorated HPMA copolymers as high-affinity lectin ligands

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recommendations! Published in 2017 at "Polymer Chemistry"

DOI: 10.1039/c7py00271h

Abstract: Novel conjugates of N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers tethered with chitooligosaccharidic epitopes of varying lengths were shown to be potent ligands of a model lectin, wheat germ agglutinin (WGA). The azide-functionalized oligosaccharidic epitopes were prepared by… read more here.

Keywords: glycan decorated; high affinity; affinity lectin; hpma copolymers ... See more keywords
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Cross-Linking Effects Dictate the Preference of Galectins to Bind LacNAc-Decorated HPMA Copolymers

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22116000

Abstract: The interaction of multi-LacNAc (GalĪ²1-4GlcNAc)-containing N-(2-hydroxypropyl) methacrylamide (HPMA) copolymers with human galectin-1 (Gal-1) and the carbohydrate recognition domain (CRD) of human galectin-3 (Gal-3) was analyzed using NMR methods in addition to cryo-electron-microscopy and dynamic light… read more here.

Keywords: microscopy; effects dictate; cross linking; hpma copolymers ... See more keywords