A review of HPRT and its emerging role in cancer
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DOI: 10.1007/s12032-018-1144-1
Abstract: Hypoxanthine guanine phosphoribosyltransferase (HPRT) is a common salvage housekeeping gene with a historically important role in cancer as a mutational biomarker. As an established and well-known human reporter gene for the evaluation of mutational frequency… read more here.
Keywords: hprt emerging; role cancer; hprt; review hprt ... See more keywords
Abstract 2536: Unique HPRT1 upregulation in malignant tissue: Potential use as diagnostic biomarker
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DOI: 10.1158/1538-7445.am2018-2536
Abstract: The aim of this study is to examine the gene expression of the purine salvage pathway enzyme Hypoxanthine Guanine Phosphribosyltransferase (HPRT) in malignant and normal tissue to determine potential upregulation. Due to the critical role… read more here.
Keywords: tissue; hprt; expression; cancer ... See more keywords
The renal phenotype of allopurinol-treated HPRT-deficient mouse
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DOI: 10.1371/journal.pone.0173512
Abstract: Excess of uric acid is mainly treated with xanthine oxidase (XO) inhibitors, also called uricostatics because they block the conversion of hypoxanthine and xanthine into urate. Normally, accumulation of upstream metabolites is prevented by the… read more here.
Keywords: hprt; xanthine; phenotype allopurinol; renal phenotype ... See more keywords
Expression variation of OGG1 and HPRT gene and DNA damage in arsenic exposed industrial workers
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DOI: 10.1371/journal.pone.0273211
Abstract: Arsenic exposure alters redox balance, induces DNA damage, and deregulates many genes. OGG1 gene involved in base repair mechanism, for excision of 8-oxoguanine (8-oxoG) from DNA formed as a result of accumulation of ROS in… read more here.
Keywords: dna damage; hprt; gene; expression ... See more keywords