PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism
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DOI: 10.7150/ijbs.77150
Abstract: MLL-AFF4 fusion gene has been discovered in acute leukemia, whether AFF4 alone plays a role in tumor, especially pancreatic tumorigenesis, is still elusive. Increasing evidence suggests that cancer cells altered nucleotide metabolism during tumorigenesis. In… read more here.
Keywords: nucleotide metabolism; pancreatic tumorigenesis; hprt1 impdh2; aff4 ... See more keywords