Cardiomyocyte Differentiation Promotes Cell Survival During Nicotinamide Phosphoribosyltransferase Inhibition Through Increased Maintenance of Cellular Energy Stores
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells Translational Medicine"
DOI: 10.1002/sctm.16-0151
Abstract: To address concerns regarding the tumorigenic potential of undifferentiated human pluripotent stem cells (hPSC) that may remain after in vitro differentiation and ultimately limit the broad use of hPSC‐derivatives for therapeutics, we recently described a… read more here.
Keywords: medicine; inhibition; hpsc; differentiation ... See more keywords
Shaking table tests and seismic design suggestions for innovative suspended ceiling systems with detachable metal panels
Sign Up to like & getrecommendations! Published in 2021 at "Engineering Structures"
DOI: 10.1016/j.engstruct.2020.111830
Abstract: Abstract Recent severe earthquakes revealed that a suspended ceiling system was one of the most fragile non-structural components in buildings, with damage to ceilings causing serious economic losses. Suspended ceilings with detachable panels are widely… read more here.
Keywords: tests seismic; table tests; ceiling; suspended ceiling ... See more keywords
Establishment of 2 control and 2 hPSC cell lines constitutively expressing the Notch ligand DLL4.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2017.07.008
Abstract: The Notch ligand DLL4 has key roles during embryonic development of different tissues, but most of the data comes from animal models. Here we describe the generation and characterization of 2 human Pluripotent Stem Cell… read more here.
Keywords: ligand dll4; notch ligand; control hpsc; hpsc ... See more keywords
Co-differentiation and enrichment of corneal endothelial cells and keratocytes from human pluripotent stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-03509-3
Abstract: Corneal keratocytes (CK) and endothelial cells (CEnC) maintain corneal stromal transparency. Damage to these cell types can lead to visual impairment. Although corneal transplantation is effective, donor shortages limit its availability. Human pluripotent stem cells… read more here.
Keywords: differentiation; hpsc; human pluripotent; corneal ... See more keywords
Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux
Sign Up to like & getrecommendations! Published in 2019 at "Stem Cells International"
DOI: 10.1155/2019/8195614
Abstract: Metabolism has been shown to alter cell fate in human pluripotent stem cells (hPSC). However, current understanding is almost exclusively based on work performed at 20% oxygen (air), with very few studies reporting on hPSC… read more here.
Keywords: oxygen; human pluripotent; hpsc; pluripotent stem ... See more keywords
In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.053563
Abstract: Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized that large-scale manufacturing of mature hPSC-CMs could… read more here.
Keywords: hpsc cms; cell; pluripotent stem; human pluripotent ... See more keywords
Abstract Thu035: Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System
Sign Up to like & getrecommendations! Published in 2025 at "Circulation Research"
DOI: 10.1161/res.137.suppl_1.thu035
Abstract: Background: Although several methods have been reported for the large-scale generation of hPSC-derived cardiomyocytes (hPSC-CMs) in bioreactors exclusively using small molecules, no comparable bioreactor-based protocol has been established using growth factors, despite evidence that differentiation… read more here.
Keywords: differentiation; hpsc; culture; cell ... See more keywords
Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12040628
Abstract: Human pluripotent stem cell (hPSC)-derived cardiomyocytes have proven valuable for modeling disease and as a drug screening platform. Here, we depict an optimized protocol for the directed differentiation of hPSCs toward cardiomyocytes with an atrial… read more here.
Keywords: rar; hpsc; retinoic acid; differentiation ... See more keywords
3D culturing of human pluripotent stem cells-derived endothelial cells for vascular regeneration
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.69938
Abstract: Rationale: Human induced pluripotent stem cell-derived endothelial cells can be candidates for engineering therapeutic vascular grafts. Methods: Here, we studied the role of three-dimensional culture on their characteristics and function both in vitro and in… read more here.
Keywords: pluripotent stem; endothelial cells; culturing human; hpsc ... See more keywords