Epigenetic Priming of Human Pluripotent Stem Cell‐Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation
Sign Up to like & getrecommendations! Published in 2019 at "STEM CELLS"
DOI: 10.1002/stem.3021
Abstract: Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) exhibit a fetal phenotype that limits in vitro and therapeutic applications. Strategies to promote cardiomyocyte maturation have focused interventions on differentiated hPSC‐CMs, but this study tests priming of early… read more here.
Keywords: hpsc cms; cardiomyocyte maturation; cardiac progenitor; pic ... See more keywords
High-Content Electrophysiological Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs).
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7553-2_12
Abstract: Considerable interest has been raised to develop human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) as a model for drug discovery and cardiotoxicity screening. High-content electrophysiological analysis of currents generated by transmembrane cell surface ion channels has… read more here.
Keywords: human pluripotent; hpsc cms; cell derived; stem cell ... See more keywords
Genome-wide analyses reveal the detrimental impacts of SARS-CoV-2 viral gene Orf9c on human pluripotent stem cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2022.01.014
Abstract: Patients with coronavirus disease 2019 (COVID-19) commonly have manifestations of heart disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome encodes 27 proteins. Currently, SARS-CoV-2 gene-induced abnormalities of human heart muscle cells remain elusive. Here,… read more here.
Keywords: stem cell; hpsc cms; gene orf9c; sars cov ... See more keywords
In Vitro Matured Human Pluripotent Stem Cell–Derived Cardiomyocytes Form Grafts With Enhanced Structure and Function in Injured Hearts
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DOI: 10.1161/circulationaha.121.053563
Abstract: Background: Human pluripotent stem cell (hPSC)–derived cardiomyocytes (hPSC-CMs) have tremendous promise for application in cardiac regeneration, but their translational potential is limited by an immature phenotype. We hypothesized that large-scale manufacturing of mature hPSC-CMs could… read more here.
Keywords: hpsc cms; cell; pluripotent stem; human pluripotent ... See more keywords
The Aurora Kinase Inhibitor CYC116 Promotes the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2022.0077
Abstract: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have great potential in applications such as regenerative medicine, cardiac disease modeling, and in vitro drug evaluation. However, hPSC-CMs are immature, which limits their applications. During development, the maturation… read more here.
Keywords: stem; hpsc cms; maturation; aurora kinase ... See more keywords
Aminophylline Induces Two Types of Arrhythmic Events in Human Pluripotent Stem Cell–Derived Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.789730
Abstract: Cardiac side effects of some pulmonary drugs are observed in clinical practice. Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may serve as an example. Data on the action of aminophylline on cardiac cell electrophysiology… read more here.
Keywords: aminophylline; hpsc cms; cell; pluripotent stem ... See more keywords