BACE2 variant identified from HSCR patient causes AD-like phenotypes in hPSC-derived brain organoids
Sign Up to like & getrecommendations! Published in 2022 at "Cell Death Discovery"
DOI: 10.1038/s41420-022-00845-5
Abstract: β-site APP-cleaving enzyme 2 (BACE2) is a homolog of BACE1, which is considered as the most promising therapeutic target for Alzheimer’s disease (AD). However, the expression and functional role of BACE2 in central nervous system… read more here.
Keywords: hscr; bace2; derived brain; brain organoids ... See more keywords
High-throughput 3D screening for differentiation of hPSC-derived cell therapy candidates
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aaz1457
Abstract: A high-throughput 3D hPSC differentiation screening strategy reveals basic and translational insight for CNS cell therapies. The emergence of several cell therapy candidates in the clinic is an encouraging sign for human diseases/disorders that currently… read more here.
Keywords: hpsc derived; cell therapy; therapy candidates; cell ... See more keywords
NK Cells from Human Pluripotent Stem Cells for Immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-115499
Abstract: Natural Killer (NK) cells are a one of innate lymphocytes and show cytotoxicity against tumour cells without prior antigen specific stimulation. . NK cells can demonstrate stronger cytotoxicity than T cells in the absence of… read more here.
Keywords: hpsc derived; cells immunotherapy; medium; derived cells ... See more keywords
Engineering induction of singular neural rosette emergence within hPSC-derived tissues
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.37549
Abstract: Human pluripotent stem cell (hPSC)-derived neural organoids display unprecedented emergent properties. Yet in contrast to the singular neuroepithelial tube from which the entire central nervous system (CNS) develops in vivo, current organoid protocols yield tissues… read more here.
Keywords: hpsc derived; tissue; rosette emergence;