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   Articles with "hpscs" as a keyword



Engineered Peptide Modified Hydrogel Platform for propagation of Human Pluripotent Stem Cells.

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recommendations! Published in 2020 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2020.06.034

Abstract: Human pluripotent stem cells (hPSCs) have enormous potential to alleviate cell needs for regenerative medicine, however these cells require expansion in cell colonies to maintain cell-cell contact, thus limiting the scalability needed to meet the… read more here.

Keywords: medicine; stem cells; human pluripotent; pluripotent stem ... See more keywords

Reprogramming tumor stroma using an endogenous lipid lipoxin A4 to treat pancreatic cancer.

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recommendations! Published in 2018 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.01.072

Abstract: Pancreatic stellate cells (PSCs) are the precursors of cancer-associated fibroblasts (CAFs), which potentiate pancreatic tumor growth and progression. In this study, we investigated whether Lipoxin A4 (LXA4), an endogenous bioactive lipid, can inhibit the differentiation… read more here.

Keywords: pancreatic cancer; hpscs; cancer; treat pancreatic ... See more keywords

Optimization of gene knockout approaches and sgRNA selection in hPSCs with inducible Cas9 expression

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-24184-4

Abstract: CRISPR/Cas9 has been extensively used for gene knockout, enabling functional studies of genetic loss-of-function in human pluripotent stem cells (hPSCs). However, commonly used Cas9 systems usually exhibit limited and variable efficiencies, and identifying single-guide RNAs… read more here.

Keywords: sgrna selection; hpscs; cas9; gene knockout ... See more keywords

ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway

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recommendations! Published in 2023 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.79095

Abstract: The mechanisms of self-renewal and pluripotency maintenance of human pluripotent stem cells (hPSCs) have not been fully elucidated, especially for the role of those poorly characterized long noncoding RNAs (lncRNAs). ESRG is a lncRNA highly… read more here.

Keywords: self renewal; hpscs; renewal pluripotency;