4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200580
Abstract: Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and… read more here.
Keywords: substituted glucuronic; hpse; glucuronic cyclophellitols; cyclophellitols selective ... See more keywords
Heparanase‐1 activity and the early postnatal prostate development
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Dynamics"
DOI: 10.1002/dvdy.12
Abstract: Ventral prostate (VP) morphogenesis starts during embryonic development and continues for the first three postnatal weeks. Heparan sulfate (HS) affects paracrine signaling. Heparanase‐1 (HPSE) is the only enzyme capable of cleaving HS. HPSE releases the… read more here.
Keywords: prostate; heparanase; hpse; epithelial growth ... See more keywords
Potential roles of heparanase in cancer therapy: Current trends and future direction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30995
Abstract: Heparanase (HPSE; heparanase‐1) is an endo‐β‐glucuronidase capable of degrading the carbohydrate moiety of heparan sulfate proteoglycans, thus modulating and facilitating the remodeling of the extracellular matrix and basement membrane. HPSE activity is strongly associated with… read more here.
Keywords: hpse; potential roles; heparanase; roles heparanase ... See more keywords
Heparanase is a regulator of natural killer cell activation and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3a0420-259rr
Abstract: Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces. Most immune cells express heparanase that contributes to a range of functions including cell migration… read more here.
Keywords: cytotoxicity; cell activation; heparanase; hpse ... See more keywords
Dual roles of heparanase in human carotid plaque calcification.
Sign Up to like & getrecommendations! Published in 2019 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.12.027
Abstract: BACKGROUND AND AIMS Calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of HPSE… read more here.
Keywords: human carotid; hpse expression; hpse; calcification ... See more keywords
Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112221
Abstract: Heparanase (HPSE)-directed tumor progression plays a crucial role in mediating tumor-host crosstalk and priming the tumor microenvironment, leading to tumor growth, metastasis and chemo-resistance. HPSE-mediated breakdown of structural heparan sulfate (HS) networks in the extracellular… read more here.
Keywords: hpse; antitumor activity; activity structure; structure activity ... See more keywords
Design Principle of Heparanase Inhibitors: A Combined In Vitro and In Silico Study.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.3c00268
Abstract: Heparanase (HPSE) is an enzyme that cleaves heparan sulfate (HS) side chains from heparan sulfate proteoglycans (HSPGs). Overexpression of HPSE is associated with various types of cancer, inflammation, and immune disorders, making it a highly… read more here.
Keywords: hpse; heparanase; principle heparanase; small molecule ... See more keywords
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00411-5
Abstract: Heparanase (HPSE) is a kind of multifunctional extracellular hydrolase, and related to metastasis of hepatocellular carcinoma (HCC). Endothelial necroptosis promotes the metastasis of cancer cells. It is not clear whether HPSE could mediate necroptosis of… read more here.
Keywords: hpse; hcc; necroptosis; metastasis ... See more keywords
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-45012-9
Abstract: Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical… read more here.
Keywords: use heparanase; regulatory cells; hpse; inflamed tissue ... See more keywords
Heparanase and macrophage interplay in the onset of liver fibrosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14946-0
Abstract: The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed… read more here.
Keywords: heparanase macrophage; hpse; fibrosis; liver fibrosis ... See more keywords
Heparanase Is a Critical Regulator of Mitotic Spindles Required for Maintaining Chromosome Stability.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3990
Abstract: The mitotic spindle, assembled by microtubule organization center (MTOC), is a critical structure required for proper chromosome segregation during mitosis. Studies demonstrated that defects of mitotic spindle assembling would result in chromosome instability, associating with… read more here.
Keywords: hpse; chromosome instability; heparanase critical; mitotic spindle ... See more keywords