4‐O‐Substituted Glucuronic Cyclophellitols are Selective Mechanism‐Based Heparanase Inhibitors
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DOI: 10.1002/cmdc.202200580
Abstract: Degradation of the extracellular matrix (ECM) supports tissue integrity and homeostasis, but is also a key factor in cancer metastasis. Heparanase (HPSE) is a mammalian ECM‐remodeling enzyme with β‐D‐endo‐glucuronidase activity overexpressed in several malignancies, and… read more here.
Keywords: substituted glucuronic; hpse; glucuronic cyclophellitols; cyclophellitols selective ... See more keywords
Heparanase‐1 activity and the early postnatal prostate development
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DOI: 10.1002/dvdy.12
Abstract: Ventral prostate (VP) morphogenesis starts during embryonic development and continues for the first three postnatal weeks. Heparan sulfate (HS) affects paracrine signaling. Heparanase‐1 (HPSE) is the only enzyme capable of cleaving HS. HPSE releases the… read more here.
Keywords: prostate; heparanase; hpse; epithelial growth ... See more keywords
Potential roles of heparanase in cancer therapy: Current trends and future direction
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30995
Abstract: Heparanase (HPSE; heparanase‐1) is an endo‐β‐glucuronidase capable of degrading the carbohydrate moiety of heparan sulfate proteoglycans, thus modulating and facilitating the remodeling of the extracellular matrix and basement membrane. HPSE activity is strongly associated with… read more here.
Keywords: hpse; potential roles; heparanase; roles heparanase ... See more keywords
Heparanase is a regulator of natural killer cell activation and cytotoxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.3a0420-259rr
Abstract: Heparanase is the only mammalian enzyme capable of cleaving heparan sulfate, a glycosaminoglycan of the extracellular matrix and cell surfaces. Most immune cells express heparanase that contributes to a range of functions including cell migration… read more here.
Keywords: cytotoxicity; cell activation; heparanase; hpse ... See more keywords
Dual roles of heparanase in human carotid plaque calcification.
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DOI: 10.1016/j.atherosclerosis.2018.12.027
Abstract: BACKGROUND AND AIMS Calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which cleaves glycosaminoglycan chains of heparan sulfate proteoglycans. The role of HPSE… read more here.
Keywords: human carotid; hpse expression; hpse; calcification ... See more keywords
Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112221
Abstract: Heparanase (HPSE)-directed tumor progression plays a crucial role in mediating tumor-host crosstalk and priming the tumor microenvironment, leading to tumor growth, metastasis and chemo-resistance. HPSE-mediated breakdown of structural heparan sulfate (HS) networks in the extracellular… read more here.
Keywords: hpse; antitumor activity; activity structure; structure activity ... See more keywords
Heparanase induces necroptosis of microvascular endothelial cells to promote the metastasis of hepatocellular carcinoma
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DOI: 10.1038/s41420-021-00411-5
Abstract: Heparanase (HPSE) is a kind of multifunctional extracellular hydrolase, and related to metastasis of hepatocellular carcinoma (HCC). Endothelial necroptosis promotes the metastasis of cancer cells. It is not clear whether HPSE could mediate necroptosis of… read more here.
Keywords: hpse; hcc; necroptosis; metastasis ... See more keywords
Heparanase and macrophage interplay in the onset of liver fibrosis
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DOI: 10.1038/s41598-017-14946-0
Abstract: The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed… read more here.
Keywords: heparanase macrophage; hpse; fibrosis; liver fibrosis ... See more keywords
Heparanase Is a Critical Regulator of Mitotic Spindles Required for Maintaining Chromosome Stability.
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DOI: 10.1089/dna.2017.3990
Abstract: The mitotic spindle, assembled by microtubule organization center (MTOC), is a critical structure required for proper chromosome segregation during mitosis. Studies demonstrated that defects of mitotic spindle assembling would result in chromosome instability, associating with… read more here.
Keywords: hpse; chromosome instability; heparanase critical; mitotic spindle ... See more keywords
AQUAPORIN-3 AND HEPARANASE GENETIC POLYMORPHISMS MAY MODULATE ANGIOGENESIS INFLUENCING THE RISK OF HYPERTENSIVE DISORDERS IN WOMEN
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000838356.42559.f0
Abstract: Objective: Preeclampsia (PE), a pregnancy complication triggered by oxidative stress and hypoxia, compromises mother and baby health and changes mother’s blood vessels increasing the risk for hypertension(HT). Aquaporin-3 (AQP3) is a water/H2O2/glycerol channel with implications… read more here.
Keywords: genetic polymorphisms; hpse; disorders women; risk ... See more keywords
LINC00657 regulate colorectal carcinoma invasion and migration by enhancing heparanase expression through recruiting SMAD family member 2
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DOI: 10.1097/cad.0000000000001323
Abstract: Long noncoding RNAs are master regulators of several cancer phenotypes, such as cell growth, apoptosis, and motility. This study is designed to resolve the relevance of LINC00657 with tumor invasion and migration and its action… read more here.
Keywords: invasion migration; linc00657 hpse; hpse; linc00657 ... See more keywords