Heparanase 1 Upregulation Promotes Tumor Progression and Is a Predictor of Low Survival for Oral Cancer
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DOI: 10.3389/fcell.2022.742213
Abstract: Background: Oral cavity cancer is still an important public health problem throughout the world. Oral squamous cell carcinomas (OSCCs) can be quite aggressive and metastatic, with a low survival rate and poor prognosis. However, this… read more here.
Keywords: low survival; oral cancer; expression; hpse1 ... See more keywords
Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1098184
Abstract: Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases.… read more here.
Keywords: hpse2; glomerulonephritis diabetic; heparanase; hpse1 ... See more keywords