NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2020.102885
Abstract: Patients with HPV associated (HPV+ve) head and neck squamous cell carcinoma (HNSCC), particularly oropharyngeal cancer, show better treatment response, higher survival rates, and lower risks of recurrence as compared to HPV-ve HNSCC patients. Despite increased… read more here.
Keywords: cancer; hpv hnscc; hnscc patients; head neck ... See more keywords
Impact of HPV status on immune responses in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2022.105774
Abstract: The main objective of our study was to understand the impact of immune cell composition and the tumor-reactivity of tumor infiltrating lymphocytes (TIL) in HPV-positive (HPV+) and HPV-negative (HPV-) head and neck squamous cell carcinoma… read more here.
Keywords: hpv; hpv hnscc; head neck; neck squamous ... See more keywords
536 Divergent cancer etiologies drive distinct B cell signatures and tertiary lymphoid structures in head and neck cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0536
Abstract: Background Current FDA-approved immunotherapies aim to reinvigorate CD8+ T cells, but the contribution of the humoral arm of the immune response in human cancer remains poorly understood. B cells within tissues can mediate anti-tumor immunity… read more here.
Keywords: hpv hnscc; hnscc patients; cancer; cell ... See more keywords
LCL161, a SMAC-mimetic, Preferentially Radiosensitizes Human Papillomavirus–negative Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1157
Abstract: Targeting inhibitor of apoptosis proteins (IAP) with second mitochondria-derived activator of caspase (SMAC) mimetics may promote cancer cell death. We tested whether cIAP1 predicts poor prognosis in head and neck squamous cell carcinoma (HNSCC) and… read more here.
Keywords: lcl161; hnscc; hpv; cell ... See more keywords
Abstract 2832: Plk1 signaling as a therapeutic target for HPV- head and neck cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2832
Abstract: Current frontline chemotherapy and radiotherapy for head and neck cancer (HNC) is insufficient as ~60% of patients relapse within two years, indicating a need to identify novel targeted therapies to improve survival outcomes for HNC… read more here.
Keywords: plk1; hnscc; hnscc cells; cancer ... See more keywords
Tertiary Lymphoid Structure Raises Survival and Immunotherapy in HPV− HNSCC
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Dental Research"
DOI: 10.1177/00220345231151685
Abstract: Immune checkpoint blockade (ICB) targeting PD-1/PD-L1 has been used for the treatment of head and neck squamous cell carcinoma (HNSCC). However, the overall response rate to ICB therapy for HNSCC remains less than 20%. It… read more here.
Keywords: icb; hnscc; tertiary lymphoid; response ... See more keywords
A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.765968
Abstract: Patients with human papillomavirus-positive squamous cell carcinoma of the head and neck (HPV+ HNSCC) have a favorable prognosis compared to those with HPV-negative (HPV−) ones. We have shown previously that HPV+ HNSCC cell lines are… read more here.
Keywords: dna damage; hpv; atm; hpv hnscc ... See more keywords
The Tumor-Specific Immune Landscape in HPV+ Head and Neck Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15061296
Abstract: Human papillomaviruses (HPVs) are the causative agent of several anogenital cancers as well as head and neck cancers, with HPV+ head and neck squamous cell carcinoma (HNSCC) becoming a rapidly growing public health issue in… read more here.
Keywords: specific immune; landscape hpv; head neck; hpv ... See more keywords