HPV integration generates a cellular super-enhancer which functions as ecDNA to regulate genome-wide transcription
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad105
Abstract: Abstract Human papillomavirus (HPV) integration is a critical step in cervical cancer development; however, the oncogenic mechanism at the genome-wide transcriptional level is still poorly understood. In this study, we employed integrative analysis on multi-omics… read more here.
Keywords: genome wide; hpv; hpv integration; integration generates ... See more keywords
Abstract LB252: HPV integration events are heterogenous, clonally selected and associated with spatially distinct transcriptomic profiles in aggressive HPV positive oropharyngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb252
Abstract: HPV positive Oropharyngeal Squamous Cell Carcinoma (HPV positive OPSCC) is rising in incidence and, for patients that recur, survival is extremely poor. Recent technological advances have led to a better understanding of patterns of HPV… read more here.
Keywords: integration events; integration; hpv; events heterogenous ... See more keywords
Polymorphisms in the non-homologous end-joining DNA repair pathway are associated with HPV integration in cervical dysplasia.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer prevention research"
DOI: 10.1158/1940-6207.capr-23-0051
Abstract: Previous evidence indicates that HPV integration status may be associated with cervical cancer development and progression. However, host genetic variation within genes that may play important roles in the viral integration process is understudied. The… read more here.
Keywords: dna repair; integration; cervical dysplasia; hpv integration ... See more keywords