The exploration of new therapeutic targets for HPV‐negative head and neck squamous cell cancer through the construction of a ceRNA network and immune microenvironment analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29615
Abstract: Previous studies have shown that human papillomavirus (HPV)‐negative patients with head and neck squamous cell cancer (HNSCC) suffer from an unsatisfactory prognosis. Long noncoding RNAs (lncRNAs) have been verified to participate in many biological processes,… read more here.
Keywords: network; analysis; cerna network; immune microenvironment ... See more keywords
Rapalogs induce non-apoptotic, autophagy-dependent cell death in HPV-negative TP53 mutant head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular carcinogenesis"
DOI: 10.1002/mc.23357
Abstract: TP53 is the most frequently mutated gene in head and neck squamous cell carcinoma (HNSCC). Patients with HPV-negative TP53 mutant HNSCC have the worst prognosis, necessitating additional agents for treatment. Since mutant p53 causes sustained activation… read more here.
Keywords: autophagy; rad001; negative muttp53; cell ... See more keywords
The cytokine milieu compromises functional capacity of tumor-infiltrating plasmacytoid dendritic cells in HPV-negative but not in HPV-positive HNSCC
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-021-02874-y
Abstract: Plasmacytoid dendritic cells (pDCs) are the most potent type I interferon-producing cells and play an important role in antiviral immunity. Tumor-infiltrating pDCs were shown to be predominantly pro-tumorigenic, with reduced ability to produce interferon alpha… read more here.
Keywords: tumor infiltrating; hpv; functional capacity; hpv negative ... See more keywords
A Unique Case of Primary EBV-Positive, HPV-Negative Nasopharyngeal Carcinoma Located in the Tonsil
Sign Up to like & getrecommendations! Published in 2020 at "Head and Neck Pathology"
DOI: 10.1007/s12105-020-01237-w
Abstract: Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). When occurring outside of the nasopharynx, they are referred to as lymphoepithelioma-like carcinomas (LELCs) and present the same morphology… read more here.
Keywords: ebv positive; positive hpv; hpv; hpv negative ... See more keywords
Oropharyngeal cancer prognosis by tumour HPV status in France: The multicentric Papillophar study.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.01.012
Abstract: AIMS To evaluate the impact of human papillomavirus (HPV) status, tobacco smoking and initial treatment approach on progression-free survival (PFS) and overall survival (OS) for oropharyngeal cancer (OPC) in France, a country where smoking declines… read more here.
Keywords: hpv status; oropharyngeal cancer; hpv; hpv positive ... See more keywords
Treatment outcomes in oropharynx cancer patients who did not complete planned curative radiotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2019.05.012
Abstract: PURPOSE To evaluate outcomes in oropharyngeal cancer (OPC) patients who did not complete their planned curative radiation therapy (RT). METHODS OPC Patients who received less than planned curative RT dose between 2002 and 2016 were… read more here.
Keywords: patients complete; bed10; planned curative; hpv ... See more keywords
Sex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset.
Sign Up to like & getrecommendations! Published in 2020 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2020.104614
Abstract: OBJECTIVES Survival in head and neck squamous cell carcinoma (HNSCC) has been associated with patient sex, typically with males experiencing poorer outcomes. It is unclear if this disparity is based in divergent tumor biology. We… read more here.
Keywords: analysis; sex; tcga; hpv positive ... See more keywords
Surgical staging identified false HPV-negative cases in a large series of invasive cervical cancers
Sign Up to like & getrecommendations! Published in 2017 at "Papillomavirus Research"
DOI: 10.1016/j.pvr.2017.10.003
Abstract: Objective We examined a large series of biopsy-proven invasive cervical cancers with surgical staging and HPV re-testing to estimate the relevance of HPV-negative cervical cancers in a Caucasian population. Methods We prospectively collected smears from… read more here.
Keywords: surgical staging; cervical cancers; negative cases; cervical cancer ... See more keywords
Elevated TLR5 expression in vivo and loss of NF-κΒ activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2020.104435
Abstract: In oropharyngeal squamous cell carcinoma (OPSCC), the expression pattern of toll-like receptors (TLRs), in comparison between human papillomavirus (HPV)-positive and -negative tumors differs. TLRs control innate immune responses by activating, among others, the nuclear factor-κΒ… read more here.
Keywords: cell; hpv negative; opscc; tlr5 expression ... See more keywords
HPV-negative tumors of the uterine cervix
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0249-1
Abstract: Human papillomaviruses (HPV) are the causative agents of virtually all cervical carcinomas. Nevertheless, a small proportion of cervical cancer are negative for HPV, although the significance of this finding remains unclear. We aimed to provide… read more here.
Keywords: negative tumors; months confidence; cervical cancer; confidence interval ... See more keywords
Targeting phosphorylation of STAT3 delays tumor growth in HPV-negative anal squamous cell carcinoma mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06643-9
Abstract: Although conventional chemoradiotherapy is effective for most anal squamous cell carcinoma (ASCC) patients, HPV-negative ASCC patients respond poorly to this treatment and new therapeutic approach is required. Our group has previously established an HPV-negative ASCC… read more here.
Keywords: ascc; model; mouse model; cell ... See more keywords