HPV+ Oropharyngeal Squamous Cell Carcinomas from patients with two tumors display synchrony of viral genomes yet discordant mutational profiles and signatures.
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DOI: 10.1093/carcin/bgaa111
Abstract: Human Papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+OPSCC) is increasing in prevalence in the United States, as are cases of patients with multiple HPV+OPSCCs (mHPV+OPSCC). mHPV+OPSCCs present a unique opportunity to examine HPV+OPSCC mutation… read more here.
Keywords: mutational profiles; hpv opsccs; squamous cell; patients two ... See more keywords