TRAF3/CYLD mutations identify a distinct subset of human papillomavirus‐associated head and neck squamous cell carcinoma
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DOI: 10.1002/cncr.30570
Abstract: The incidence of human papillomavirus (HPV)‐associated (HPV‐positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV‐positive HNSCCs in the United… read more here.
Keywords: neck squamous; hnscc; hpv; human papillomavirus ... See more keywords
Stage I HPV‐positive oropharyngeal cancer: Should all patients receive similar treatments?
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DOI: 10.1002/cncr.32501
Abstract: Patients with clinical stage I human papillomavirus (HPV)–positive oropharyngeal squamous cell cancer (OPSCC) according to the American Joint Committee on Cancer (AJCC) eighth edition classification comprise a heterogeneous group formerly classified as stage I to… read more here.
Keywords: positive oropharyngeal; oropharyngeal cancer; stage hpv; cancer ... See more keywords
Stratifying HPV‐positive women for CIN3+ risk after one and two rounds of HPV‐based screening
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DOI: 10.1002/ijc.30865
Abstract: A main challenge of human papilloma (HPV)‐based screening for cervical cancer is to adequately identify HPV‐positive women at highest risk of cervical intraepithelial neoplasia grade 3 or worse, CIN3+. The prognostic value of currently used… read more here.
Keywords: risk; positive women; hpv positive; cytology ... See more keywords
Eurogin roadmap 2017: Triage strategies for the management of HPV‐positive women in cervical screening programs
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DOI: 10.1002/ijc.31261
Abstract: Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the… read more here.
Keywords: cervical screening; eurogin roadmap; triage strategies; hpv positive ... See more keywords
Effects of Metformin on the virus/host cell crosstalk in human papillomavirus‐positive cancer cells
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DOI: 10.1002/ijc.33594
Abstract: Oncogenic types of human papillomaviruses (HPVs) are major human carcinogens. The viral E6/E7 oncogenes maintain the malignant growth of HPV‐positive cancer cells. Targeted E6/E7 inhibition results in efficient induction of cellular senescence, which could be… read more here.
Keywords: positive cancer; senescence; cancer cells; cancer ... See more keywords
Clinical Validation of p16/Ki-67 Dual-Stained Cytology Triage of HPV-Positive Women - Results from the IMPACT Trial.
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DOI: 10.1002/ijc.33812
Abstract: Triage strategies are needed for primary human papillomavirus (HPV)-based cervical cancer screening to identify women requiring colposcopy/biopsy. We assessed the performance of p16/Ki-67 dual-stained immunocytochemistry (DS) to triage HPV-positive women and compared it to cytology,… read more here.
Keywords: triage hpv; hpv positive; cytology; positive women ... See more keywords
Accuracy of Different Triage Strategies for HPV Positivity in an Italian Screening Population.
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DOI: 10.1002/ijc.33858
Abstract: How to manage HPV-positive women in cervical cancer screening is still debated. This study compared different strategies to triage HPV positivity in a large cohort of women participating in a population HPV-based screening programme. Women… read more here.
Keywords: cytology; hpv positive; p16 ki67; hpv positivity ... See more keywords
Continuing Professional Development
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DOI: 10.1002/jmrs.367
Abstract: a. 125% increase in HPV-positive oropharyngeal carcinoma, and 50% decrease in HP-negative oropharyngeal carcinoma b. 225% increase in HPV-positive oropharyngeal carcinoma, and 70% decrease in HP-negative oropharyngeal carcinoma c. 225% decrease in HPV-positive oropharyngeal carcinoma,… read more here.
Keywords: carcinoma; hpv positive; negative oropharyngeal; oropharyngeal carcinoma ... See more keywords
Dual staining for p16/Ki67 is a more specific test than cytology for triage of HPV-positive women
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DOI: 10.1007/s00428-018-2432-z
Abstract: Globally, cervical cancer (CC) screening is moving from cytology-based to HPV screening or a combination of both (co-testing). Most HPV-positive women clear the virus and do not develop relevant disease. Additional triage approaches are needed… read more here.
Keywords: p16 ki67; positive women; cytology; hpv positive ... See more keywords
Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
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DOI: 10.1007/s12262-016-1585-8
Abstract: Head and neck squamous cell carcinomas (HNSCCs) are the most common cancers in India. Association, clinical presentations, and pathology of human papillomavirus (HPV) infection in 50 HNSCC patients were assessed and compared with 50 patients… read more here.
Keywords: hnscc; hpv; hpv positive; hnscc patients ... See more keywords
Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3
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DOI: 10.1007/s13577-018-00225-1
Abstract: This study explores the role of miR-93-5p in high-risk HPV-positive (HR-HPV) cervical cancer by targeting of BTG3. Cervical tissues were collected from 332 patients with conditions of chronic cervicitis (n = 42), low-grade cervical intraepithelial neoplasia (CIN… read more here.
Keywords: btg3; mir; cervical cancer; cancer ... See more keywords