Human papillomavirus‐16 E6‐positive cervical cancer attenuated by potent 2‐(4‐biphenylyl)‐N‐(1‐ethyl‐4‐piperidinyl) acetamide second‐generation analogs with improved binding affinity
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DOI: 10.1002/bab.2639
Abstract: Human papillomavirus (HPV) infection, particularly HPV16, is a major contributor to the development of cervical cancer. Given the urgent need for novel therapeutic strategies targeting HPV‐associated cancers, this study focuses on characterizing second‐generation analogs of… read more here.
Keywords: hpv16; second generation; human papillomavirus; cervical cancer ... See more keywords
Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study.
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DOI: 10.1002/cncr.34783
Abstract: BACKGROUND Human papillomavirus (HPV)-related oropharyngeal cancer screening is being explored in research studies, but strategies to identify an appropriate population are not established. The authors evaluated whether a screening population could be enriched for participants… read more here.
Keywords: prevalence; hpv; human papillomavirus; hpv16 ... See more keywords
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1
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DOI: 10.1002/ijc.31876
Abstract: HPV16 is the predominant type of HPV causing invasive cervical cancer. However, the underlying molecular mechanism of the unparalleled carcinogenic power of HPV16 compared to other types of high‐risk (HR)‐HPV including HPV18 remains elusive. The… read more here.
Keywords: cervical cancer; hpv16; downregulation; cancer ... See more keywords
Assessment of the effectiveness of HPV16/18 infection referred for colposcopy in cervical cancer screening in Northwest of China
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DOI: 10.1002/jmv.24902
Abstract: To evaluate the effectiveness of Human papillomavirus16/18 infection referral to colposcopy in cervical cancer screening for women aged 25 years and older in Chinese northwest region Shaan'xi province. A total of 2224 women were diagnosed… read more here.
Keywords: referred colposcopy; cancer screening; infection; cervical cancer ... See more keywords
Naturally developed HPV16 antibodies and risk of newly detected cervical HPV infection outcomes
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DOI: 10.1002/jmv.29608
Abstract: Little is known about the protection conferred by antibodies from natural human papillomavirus (HPV) infection. Our objective was to evaluate the association between HPV16 seroreactivity and HPV16 redetection, newly detected HPV infections, and loss of… read more here.
Keywords: hpv; newly detected; hpv infections; hpv16 ... See more keywords
Changes in intrahost genetic diversity according to lesion severity in longitudinal HPV16 samples
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DOI: 10.1002/jmv.29641
Abstract: Human papillomavirus type 16 (HPV16) is the most common cause of cervical cancer, but most infections are transient with lesions not progressing to cancer. There is a lack of specific biomarkers for early cancer risk… read more here.
Keywords: lesion severity; grade; hpv16; high grade ... See more keywords
Development of HPV16,18,31,45 E5 and E7 peptides-based vaccines predicted by immunoinformatics tools
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DOI: 10.1007/s10529-020-02792-6
Abstract: Viral oncoproteins are ideal targets in therapeutic vaccines for functional inhibition of human papillomaviruses (HPVs). Herein, we designed the peptide constructs derived from E5 and E7 oncoproteins of high-risk HPV types 16, 18, 31 and… read more here.
Keywords: high risk; risk hpv; hpv16; development hpv16 ... See more keywords
Response to: “Study results and related evidence do not support use of HPV16 L1 DRH1 antibodies as a cancer screening test”
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DOI: 10.1016/j.ebiom.2020.103139
Abstract: We value all comments on our research, and the opportunity to provide further information on our study describing the HPV16-specific tumour marker DRH1 [1]. We used an assay that was CE certified under the European… read more here.
Keywords: response study; study; hpv16; test ... See more keywords
Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer.
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DOI: 10.1016/j.oraloncology.2017.08.014
Abstract: OBJECTIVE The aim of this study was to determine the association of HPV16 antibodies (Abs) and oropharyngeal cancer (OPC) risk in sera obtained prior to clinical diagnosis. METHODS We identified 92 participants with incident OPC… read more here.
Keywords: oropharyngeal cancer; diagnosis; seropositivity; igg seropositivity ... See more keywords
Efficient production of HPV16 E2 protein from HPV16 late mRNAs spliced from SD880 to SA2709.
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DOI: 10.1016/j.virusres.2020.198004
Abstract: Human papillomaviruses (HPVs) produce a large number of alternatively spliced mRNAs, including a number of differently spliced mRNAs with the potential to produce E2 protein. To identify the alternatively spliced HPV16 mRNA with the highest… read more here.
Keywords: protein; hpv16; splice site; hpv16 late ... See more keywords
Co-infections of HPV16/18 with other high-risk HPV types and the risk of cervical carcinogenesis: A large population-based study.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.10.003
Abstract: OBJECTIVE Human papillomavirus (HPV) 16/18 genotyping is an effective method for triage of high-risk (hr) HPV-positive women in primary hrHPV screening for cervical cancer. The present study aimed to evaluate whether co-infected with other hrHPV… read more here.
Keywords: risk; cervical carcinogenesis; hpv16 infection; risk cervical ... See more keywords