Prevalence of oral and blood oncogenic human papillomavirus biomarkers among an enriched screening population: Baseline results of the MOUTH study.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer"
DOI: 10.1002/cncr.34783
Abstract: BACKGROUND Human papillomavirus (HPV)-related oropharyngeal cancer screening is being explored in research studies, but strategies to identify an appropriate population are not established. The authors evaluated whether a screening population could be enriched for participants… read more here.
Keywords: prevalence; hpv; human papillomavirus; hpv16 ... See more keywords
HPV16 E6 promotes cervical cancer cell migration and invasion by downregulation of NHERF1
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DOI: 10.1002/ijc.31876
Abstract: HPV16 is the predominant type of HPV causing invasive cervical cancer. However, the underlying molecular mechanism of the unparalleled carcinogenic power of HPV16 compared to other types of high‐risk (HR)‐HPV including HPV18 remains elusive. The… read more here.
Keywords: cervical cancer; hpv16; downregulation; cancer ... See more keywords
Assessment of the effectiveness of HPV16/18 infection referred for colposcopy in cervical cancer screening in Northwest of China
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.24902
Abstract: To evaluate the effectiveness of Human papillomavirus16/18 infection referral to colposcopy in cervical cancer screening for women aged 25 years and older in Chinese northwest region Shaan'xi province. A total of 2224 women were diagnosed… read more here.
Keywords: referred colposcopy; cancer screening; infection; cervical cancer ... See more keywords
Development of HPV16,18,31,45 E5 and E7 peptides-based vaccines predicted by immunoinformatics tools
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DOI: 10.1007/s10529-020-02792-6
Abstract: Viral oncoproteins are ideal targets in therapeutic vaccines for functional inhibition of human papillomaviruses (HPVs). Herein, we designed the peptide constructs derived from E5 and E7 oncoproteins of high-risk HPV types 16, 18, 31 and… read more here.
Keywords: high risk; risk hpv; hpv16; development hpv16 ... See more keywords
Response to: “Study results and related evidence do not support use of HPV16 L1 DRH1 antibodies as a cancer screening test”
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DOI: 10.1016/j.ebiom.2020.103139
Abstract: We value all comments on our research, and the opportunity to provide further information on our study describing the HPV16-specific tumour marker DRH1 [1]. We used an assay that was CE certified under the European… read more here.
Keywords: response study; study; hpv16; test ... See more keywords
Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Oral oncology"
DOI: 10.1016/j.oraloncology.2017.08.014
Abstract: OBJECTIVE The aim of this study was to determine the association of HPV16 antibodies (Abs) and oropharyngeal cancer (OPC) risk in sera obtained prior to clinical diagnosis. METHODS We identified 92 participants with incident OPC… read more here.
Keywords: oropharyngeal cancer; diagnosis; seropositivity; igg seropositivity ... See more keywords
Efficient production of HPV16 E2 protein from HPV16 late mRNAs spliced from SD880 to SA2709.
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DOI: 10.1016/j.virusres.2020.198004
Abstract: Human papillomaviruses (HPVs) produce a large number of alternatively spliced mRNAs, including a number of differently spliced mRNAs with the potential to produce E2 protein. To identify the alternatively spliced HPV16 mRNA with the highest… read more here.
Keywords: protein; hpv16; splice site; hpv16 late ... See more keywords
Co-infections of HPV16/18 with other high-risk HPV types and the risk of cervical carcinogenesis: A large population-based study.
Sign Up to like & getrecommendations! Published in 2019 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.10.003
Abstract: OBJECTIVE Human papillomavirus (HPV) 16/18 genotyping is an effective method for triage of high-risk (hr) HPV-positive women in primary hrHPV screening for cervical cancer. The present study aimed to evaluate whether co-infected with other hrHPV… read more here.
Keywords: risk; cervical carcinogenesis; hpv16 infection; risk cervical ... See more keywords
HPV16 E6 and E7 upregulate the histone lysine demethylase KDM2B through the c-MYC/miR-146a-5p axys
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DOI: 10.1038/s41388-017-0083-1
Abstract: Persistent infection by high-risk human papillomaviruses (HPVs) is associated with the development of cervical cancer and a subset of anogenital and head and neck squamous cell carcinomas. Abnormal expression of cellular microRNAs (miRNAs) plays an… read more here.
Keywords: demethylase kdm2b; mir 146a; hpv16; cancer ... See more keywords
The application of CRISPR/Cas9 system in cervical carcinogenesis.
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DOI: 10.1038/s41417-021-00366-w
Abstract: Integration of high-risk HPV genomes into cellular chromatin has been confirmed to promote cervical carcinogenesis, with HPV16 being the most prevalent high-risk type. Herein, we evaluated the therapeutic effect of the CRISPR/Cas9 system in cervical… read more here.
Keywords: crispr cas9; hpv16; cervical carcinogenesis;
miR-4454 up-regulated by HPV16 E6/E7 promotes invasion and migration by targeting ABHD2/NUDT21 in cervical cancer
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DOI: 10.1042/bsr20200796
Abstract: Abstract The abnormal expression of HPV16 E6/E7 activates oncogenes and/or inactivates tumor suppressor genes, resulting in the selective growth and malignant transformation of cancer cells. miR-4454 was selected by sequencing due to its abnormal high… read more here.
Keywords: hpv16; abhd2 nudt21; mir 4454; invasion migration ... See more keywords