Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model
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DOI: 10.3389/fcell.2022.1000575
Abstract: RAS GTPases are ubiquitous GDP/GTP-binding proteins that function as molecular switches in cellular signalling and control numerous signalling pathways and biological processes. Pathogenic mutations in RAS genes severely affect cellular homeostasis, leading to cancer when… read more here.
Keywords: hras g12v; costello syndrome; bone loss; increased osteoclastogenesis ... See more keywords