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   Articles with "hrd" as a keyword



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Homologous recombination repair deficiency (HRD): From biology to clinical exploitation

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recommendations! Published in 2021 at "Genes"

DOI: 10.1002/gcc.22939

Abstract: Significant advances in cancer precision medicine over the last decade have led to a number of treatment options that have significantly improved patient outcomes. The underlying concept integrates detailed insights into disease mechanisms with clinical… read more here.

Keywords: hrd; homologous recombination; biology; recombination repair ... See more keywords

Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma.

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recommendations! Published in 2022 at "Journal of clinical laboratory analysis"

DOI: 10.1002/jcla.24277

Abstract: BACKGROUND Lung adenocarcinoma (LUAD) is a lung cancer subtype with poor prognosis. We investigated the prognostic value of methylation- and homologous recombination deficiency (HRD)-associated gene signatures in LUAD. METHODS Data on RNA sequencing, somatic mutations,… read more here.

Keywords: lung; methylation; prognosis; methylation homologous ... See more keywords

Industrial furnaces with thermochemical waste-heat recuperation by coal gasification

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recommendations! Published in 2021 at "Energy"

DOI: 10.1016/j.energy.2021.119864

Abstract: Abstract A thermochemical waste-heat recuperation (TCR) system by coal gasification is considered. Two concepts of TCR were analyzed: gasification with steam and gasification with the steam-flue gas mixture. To determine the effectiveness of using TCR… read more here.

Keywords: coal gasification; heat; hrd; recuperation ... See more keywords

Clinical assays for assessment of homologous recombination DNA repair deficiency.

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recommendations! Published in 2020 at "Gynecologic oncology"

DOI: 10.1016/j.ygyno.2020.09.029

Abstract: Homologous recombination DNA repair deficiency (HRD) is a functional defect in homologous recombination DNA repair, arising from germline or somatic mutations in BRCA1/2 or other mechanisms. Cells with HRD are more sensitive to platinum and… read more here.

Keywords: recombination dna; dna repair; dna; hrd ... See more keywords

ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors

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recommendations! Published in 2024 at "British Journal of Cancer"

DOI: 10.1038/s41416-024-02745-0

Abstract: PARP inhibitors (PARPi) are effective in homologous recombination repair (HRR) defective (HRD) cancers. To (re)sensitise HRR proficient (HRP) tumours to PARPi combinations with other drugs are being explored. Our aim was to determine the mechanism… read more here.

Keywords: atr chk1; chk1 wee1; homologous recombination; parp inhibitors ... See more keywords
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What are the (C)HRD implications of Brexit? A personal reflection?

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recommendations! Published in 2017 at "Human Resource Development International"

DOI: 10.1080/13678868.2017.1237420

Abstract: This extended editorial by Professor Jim Stewart is the first example of a ‘quick response’ to contemporary events which I would like to become a regular feature in our journal. An advantage of digital technology… read more here.

Keywords: hrd implications; implications brexit; hrd; cms listserve ... See more keywords
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Under western eyes: A transnational and postcolonial perspective of gender and HRD

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recommendations! Published in 2017 at "Human Resource Development International"

DOI: 10.1080/13678868.2017.1329367

Abstract: ABSTRACT Much of the critical research on human resource development (HRD) is positioned within Western constructions of knowledge and orthodoxy. Barring a few exceptions (e.g. there is little critique of the ‘colonial boundaries’ for how… read more here.

Keywords: transnational postcolonial; hrd; gender; western eyes ... See more keywords

HRD professional education provision in the UK: past, present and future

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recommendations! Published in 2020 at "Human Resource Development International"

DOI: 10.1080/13678868.2020.1775039

Abstract: ABSTRACT The professionalization of occupations has led to the increased demand for specialized knowledge in many fields, in response to which Higher Education (HE) institutions have provided professional education programmes. The purpose of this paper… read more here.

Keywords: human resource; hrd; provision; education ... See more keywords
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Strategic flexibility analysis of HRD research and practice post COVID-19 pandemic

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recommendations! Published in 2020 at "Human Resource Development International"

DOI: 10.1080/13678868.2020.1779169

Abstract: ABSTRACT While governments, intergovernmental organizations, non-profits, corporations are all aware that disruptions through pandemics and other natural bio-disasters like the COVID-19 pandemic can happen, barely are we proactive about them. Instead, we are always reactive.… read more here.

Keywords: hrd; covid pandemic; research practice; post covid ... See more keywords
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Redefining, relooking, redesigning, and reincorporating HRD in the post Covid 19 context and thereafter

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recommendations! Published in 2020 at "Human Resource Development International"

DOI: 10.1080/13678868.2020.1780077

Abstract: ABSTRACT The COVID-19 pandemic has brought several challenges to the way organizations were functioning globally. Considering the case of India, this is a time of complete work transformation for the entire workforce across all sectors… read more here.

Keywords: hrd; covid context; relooking redesigning; covid pandemic ... See more keywords

Revolutionizing HRD through digitalization

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recommendations! Published in 2024 at "Human Resource Development International"

DOI: 10.1080/13678868.2024.2399492

Abstract: ABSTRACT Technology and its applications have had a significant impact on human resource development (HRD), and they will continue to do so at an ever-increasing speed. We used our a priori opinions and experiences to… read more here.

Keywords: hrd digitalization; hrd; development; revolutionizing hrd ... See more keywords