HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple‐negative breast cancer
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12856
Abstract: Dependence on glutamine and acceleration of fatty acid oxidation (FAO) are both metabolic characteristics of triple‐negative breast cancer (TNBC). With the rapid growth of tumors, accelerated glutamine catabolism depletes local glutamine, resulting in glutamine deficiency.… read more here.
Keywords: negative breast; hrd1; fatty acid; breast cancer ... See more keywords
HRD1 functions as a tumor suppressor in ovarian cancer by facilitating ubiquitination-dependent SLC7A11 degradation
Sign Up to like & getrecommendations! Published in 2023 at "Cell Cycle"
DOI: 10.1080/15384101.2023.2178102
Abstract: ABSTRACT The E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl reductase degradation (HRD1) was found to be a tumor suppressor in diverse types of cancers; we aimed to explore its expression pattern and biological function in ovarian cancer (OC).… read more here.
Keywords: hrd1; cell; slc7a11; degradation ... See more keywords
Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.206847
Abstract: ABSTRACT The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin–proteasome-dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD, but their… read more here.
Keywords: degradation; degradation erad; hrd1; ubiquitin ligase ... See more keywords
HRD1 sensitizes breast cancer cells to Tamoxifen by promoting S100A8 degradation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15797
Abstract: Estrogen receptor alpha positive (ER+) of breast cancer could develop resistance to antiestrogens including Tamoxifen. Our previous study showed that the E3 ubiquitin ligase HRD1 played an important role in anti-breast cancer. However, its role… read more here.
Keywords: cells tamoxifen; hrd1; s100a8; breast cancer ... See more keywords
ATRA protects skin fibroblasts against UV-induced oxidative damage through inhibition of E3 ligase Hrd1
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2019.10450
Abstract: All‑trans retinoic acid (ATRA) can protect fibroblasts against ultraviolet (UV)‑induced oxidative damage, however, its underlying molecular mechanism is still unclear. The present study aimed to investigate the role of 3‑hydroxy‑3‑methylglutaryl reductase degradation (Hrd1) in the protective… read more here.
Keywords: oxidative damage; hrd1; induced oxidative; expression ... See more keywords