A protective role of Heme-regulated eIF2α kinase in cadmium-induced liver and kidney injuries.
Sign Up to like & getrecommendations! Published in 2017 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2017.07.018
Abstract: A number of studies have reported that cadmium (Cd) can incur liver and kidney injuries. The recruitment and activation of leukocytes have been demonstrated to be involved in Cd-induced biological effects. Ironically, activated leukocytes and… read more here.
Keywords: liver kidney; kidney injuries; heme regulated; hri ... See more keywords
HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.11.071
Abstract: The Heme Regulated Inhibitor (HRI) is a key regulator of protein synthesis in mammalian cells. Once activated under heme-deficiency and other stress conditions, it phosphorylates the α subunit of eukaryotic initiation factor 2 (eIF2α) leading… read more here.
Keywords: temperature; kinase; hri; high temperature ... See more keywords
Estimating the Burden of Heat‐Related Illness Morbidity Attributable to Anthropogenic Climate Change in North Carolina
Sign Up to like & getrecommendations! Published in 2022 at "GeoHealth"
DOI: 10.1029/2022gh000636
Abstract: Climate change is known to increase the frequency and intensity of hot days (daily maximum temperature ≥30°C), both globally and locally. Exposure to extreme heat is associated with numerous adverse human health outcomes. This study… read more here.
Keywords: climate change; climate; anthropogenic climate; hri ... See more keywords
Late-Stage Pancreatic Cancer Detected During High-Risk Individual Surveillance: A Systematic Review and Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.11.021
Abstract: BACKGROUND AND AIMS Identification and resection of successful targets, i.e., T1 N0M0 pancreatic ductal adenocarcinoma (PDAC) and high-grade precursors during surveillance of high-risk individuals (HRIs) confers improved survival. Late-stage PDACs refer to T2-4 N0M0 and… read more here.
Keywords: late stage; stage pdacs; surveillance; hri ... See more keywords
The eIF2-alpha kinase HRI: a potential target beyond the red blood cell
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Targets"
DOI: 10.1080/14728222.2017.1397133
Abstract: ABSTRACT Introduction: The eIF2α kinase heme-regulated inhibitor (HRI) is one of four well-described kinases that phosphorylate eIF2α in response to various cell stressors, resulting in reduced ternary complex formation and attenuation of mRNA translation. Although… read more here.
Keywords: kinase; hri; eif2 kinase; kinase hri ... See more keywords
Translational control by heme-regulated elF2α kinase during erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000704
Abstract: Purpose of review HRI is the heme-regulated elF2α kinase that phosphorylates the α-subunit of elF2. Although the role of HRI in inhibiting globin synthesis in erythroid cells is well established, broader roles of HRI in… read more here.
Keywords: heme regulated; erythropoiesis; hri; elf2 kinase ... See more keywords
Liver Ultrasound Attenuation
Sign Up to like & getrecommendations! Published in 2022 at "Ultrasound Quarterly"
DOI: 10.1097/ruq.0000000000000605
Abstract: Objectives Nonalcoholic fatty liver disease (NAFLD) is the most widespread chronic liver disease type in the Western countries. Ultrasound (US) is used for NAFLD and hepatic steatosis (HS) grading. The most popular US method for… read more here.
Keywords: lisa hri; liver ultrasound; ultrasound attenuation; hri ... See more keywords
Drawing parallels in human–other interactions: a trans-disciplinary approach to developing human–robot interaction methodologies
Sign Up to like & getrecommendations! Published in 2019 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2018.0433
Abstract: This opinion paper discusses how human–robot interaction (HRI) methodologies can be robustly developed by drawing on insights from fields outside of HRI that explore human–other interactions. The paper presents a framework that draws parallels between… read more here.
Keywords: trans disciplinary; hri; robot; interaction ... See more keywords
Android as a Receptionist in a Shopping Mall Using Inverse Reinforcement Learning
Sign Up to like & getrecommendations! Published in 2022 at "IEEE Robotics and Automation Letters"
DOI: 10.1109/lra.2022.3180042
Abstract: For human-robot interaction (HRI), it is difficult to hand-craft all the rules for robots owing to diverse situations. Therefore, inverse reinforcement learning (IRL) is a potential solution that helps transfer human knowledge about interactions to… read more here.
Keywords: inverse reinforcement; shopping mall; reinforcement learning; hri ... See more keywords
Abstract 4959: TIC10/ONC201 activates ClpP to degrade ALAS1 while PG3 does not degrade ALAS1 in pathway to HRI, ATF4 and CHOP activation leading to tumor cell death
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4959
Abstract: TRAIL-inducing compound TIC10/ONC201 binds and activates mitochondrial protease ClpP leading to integrated stress response (ISR) and ATF4 transcription factor activation. Our lab previously reported that ONC201 activates HRI (heme-regulated inhibitor) kinase but does not signal… read more here.
Keywords: hri; clpp; degrade alas1; activation ... See more keywords
Nanosecond pulsed electric fields induce the integrated stress response via reactive oxygen species-mediated heme-regulated inhibitor (HRI) activation
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229948
Abstract: The integrated stress response (ISR) is one of the most important cytoprotective mechanisms and is integrated by phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α). Four eIF2α kinases, heme-regulated inhibitor (HRI),… read more here.
Keywords: electric fields; response; kinase; eif2 kinase ... See more keywords