Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis
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DOI: 10.1126/scitranslmed.aaf9377
Abstract: Previously parasitized erythrocytes in patients with severe malaria retain the parasite protein HRP2, which can be used to predict hemolysis induced by the drug artesunate. A quick test to predict artesunate-induced anemia Anemia frequently affects… read more here.
Keywords: red blood; hrp2; artesunate treated; blood ... See more keywords
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda
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DOI: 10.1186/s12936-023-04830-w
Abstract: Background Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda, but deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis and surveillance tools. Methods A… read more here.
Keywords: pfhrp2; plasmodium; pfhrp3 gene; gene ... See more keywords
Widespread pfhrp2/3 deletions and HRP2-based false-negative results in southern Ethiopia
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DOI: 10.1186/s12936-024-04904-3
Abstract: Background Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasmodium falciparum infection. However, the evolution and… read more here.
Keywords: pfhrp2 deletions; pfhrp2; falciparum; false negative ... See more keywords
First field evaluation of novel LDH- and HRP2-based rapid tests for Plasmodium vivax and Plasmodium falciparum malaria diagnosis
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DOI: 10.1371/journal.pntd.0013307
Abstract: Background: Rapid diagnostic tests (RDTs) are crucial for malaria diagnosis. Where Plasmodium falciparum and Plasmodium vivax are co-endemic, and where P. falciparum hrp2/3 deletions are frequent, RDTs need to detect either species, and P. falciparum… read more here.
Keywords: rdts; ldh; diagnosis; falciparum ... See more keywords