PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
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DOI: 10.1038/s41375-020-0737-9
Abstract: In classical Hodgkin lymphoma (cHL)—characterized by the presence of Hodgkin and Reed-Sternberg (HRS) cells—tumor-associated macrophages (TAMs) play a pivotal role in tumor formation. However, the significance of direct contact between HRS cells and TAMs has… read more here.
Keywords: trogocytosis; classical hodgkin; hrs; hrs cells ... See more keywords
Classical Hodgkin lymphoma producing macrophage colony‐stimulating factor with resultant monocytosis
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DOI: 10.1111/bjh.14416
Abstract: A 71-year-old Japanese woman presented with a fever of 38°C and weight loss. The results of her blood analysis were as follows: white blood cell count 4 8 9 10/l (58% neutrophils, 21% lymphocytes, 20%… read more here.
Keywords: classical hodgkin; stimulating factor; macrophage colony; colony stimulating ... See more keywords
Single-Cell Analysis of the Classical Hodgkin Lymphoma Immune Environment Reveals a Clonally-Expanded CD8+ T Cell Population with a Cytotoxic Phenotype
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DOI: 10.1182/blood-2020-137171
Abstract: Introduction: Classical Hodgkin lymphoma (cHL) is characterized by a robust and complex immune cell infiltrate and the rare presence of malignant Hodgkin-Reed-Sternberg (HRS) cells. At the genetic level, HRS cells recurrently acquire alterations that lead… read more here.
Keywords: research funding; hrs cells; cd8; cell ... See more keywords
SMAD1 promoter hypermethylation and lack of SMAD1 expression in Hodgkin lymphoma: a potential target for hypomethylating drug therapy
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DOI: 10.3324/haematol.2020.249276
Abstract: Hodgkin lymphoma (HL) is an immunologically active lymphoid neoplasm composed of a few (usually 1-10%) neoplastic Hodgkin and Reed-Sternberg (HRS) cells or lymphocyte-predominant (LP) cells and >90% non-neoplastic cells, mainly Tand B-lymphocytes, plasma cells, macrophages,… read more here.
Keywords: hrs cells; tumor; smad1 expression; smad1 ... See more keywords
The Hodgkin Lymphoma Immune Microenvironment: Turning Bad News into Good
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DOI: 10.3390/cancers14051360
Abstract: Simple Summary Classic Hodgkin lymphoma (cHL) is one of the most enigmatic study models of the tumor microenvironment (TME), in which the Hodgkin–Reed Sternberg (HRS) cells are distributed throughout an abundant but ineffective immune ecosystem.… read more here.
Keywords: hodgkin; cell; hodgkin lymphoma; hrs cells ... See more keywords