Construction of paclitaxel-based antibody–drug conjugates with a PEGylated linker to achieve superior therapeutic index
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00247-y
Abstract: Dear Editor, The selection of linkers and payloads plays a crucial role in determining the therapeutic indices of antibody–drug conjugates (ADCs). Valine–citrulline (Val–Cit) coupled with a self-immolative ρ-aminobenzyl (PAB) spacer as a cleavable dipeptide linker,… read more here.
Keywords: hrs7; sn38; ptx; drug ... See more keywords