Arginase 1 expression is increased during hepatic stellate cell activation and facilitates collagen synthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30403
Abstract: Activation of hepatic stellate cells (HSC) is a key event in the initiation of liver fibrosis. Activated HSCs proliferate and secrete excessive amounts of extracellular matrix (ECM), disturbing liver architecture and function, leading to fibrosis… read more here.
Keywords: arginase; expression increased; hsc activation; expression ... See more keywords
SOD3 deficiency induces liver fibrosis by promoting hepatic stellate cell activation and epithelial–mesenchymal transition
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30174
Abstract: Hepatic stellate cell (HSC) activation plays an important role in the pathogenesis of liver fibrosis, and epithelial–mesenchymal transition (EMT) is suggested to potentially promote HSC activation. Superoxide dismutase 3 (SOD3) is an extracellular antioxidant defense… read more here.
Keywords: sod3 deficiency; hsc activation; activation; liver fibrosis ... See more keywords
NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1586-5
Abstract: Long non-coding RNAs (lncRNAs) have been reported to be involved in many important biological processes including proliferation, apoptosis, differentiation, and survival. Recently, nuclear paraspeckle assembly transcript 1 (NEAT1), a novel lncRNA, serves as a crucial… read more here.
Keywords: hsc activation; neat1; mir 122; liver fibrosis ... See more keywords
Transcriptional regulation of Hepatic Stellate Cell activation in NASH
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DOI: 10.1038/s41598-019-39112-6
Abstract: Non-alcoholic steatohepatitis (NASH) signified by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis is a growing cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma. Hepatic fibrosis resulting from accumulation of extracellular matrix proteins secreted by… read more here.
Keywords: hsc activation; disease; nash; activation ... See more keywords
Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways.
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DOI: 10.1111/jfbc.14463
Abstract: Resveratrol, which is a natural polyphenol found in grapes, berries, peanuts, and medicinal plants, has previously been reported to perform several biological functions, including inhibition of hepatic fibrosis. Activated hepatic stellate cells (HSCs) are the… read more here.
Keywords: autophagy apoptosis; apoptosis; resveratrol; hsc activation ... See more keywords
Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling
Sign Up to like & getrecommendations! Published in 2019 at "Gut"
DOI: 10.1136/gutjnl-2018-317872
Abstract: Objective Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated the role of GDNF in hepatic… read more here.
Keywords: cell; hsc activation; liver fibrosis; gdnf ... See more keywords
Epiregulin (EREG) and Myocardin Related Transcription Factor A (MRTF-A) Form a Feedforward Loop to Drive Hepatic Stellate Cell Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.591246
Abstract: Trans-differentiation of quiescent hepatic stellate cells (HSC) into myofibroblast cells is considered the linchpin of liver fibrosis. A myriad of signaling pathways contribute to HSC activation and consequently liver fibrosis. Epidermal growth factor (EGF) family… read more here.
Keywords: transcription; hsc activation; activation; ereg ... See more keywords
Down-Regulation of CXXC5 De-Represses MYCL1 to Promote Hepatic Stellate Cell Activation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.680344
Abstract: Liver fibrosis is mediated by myofibroblasts, a specialized cell type involved in wound healing and extracellular matrix production. Hepatic stellate cells (HSC) are the major source of myofibroblasts in the fibrotic livers. In the present… read more here.
Keywords: cxxc5; hsc activation; regulation cxxc5; activation ... See more keywords
The Phenylethanol Glycoside Liposome Inhibits PDGF-Induced HSC Activation via Regulation of the FAK/PI3K/Akt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24183282
Abstract: Cistanche tubulosa is a traditional Chinese herbal medicine that is widely used to regulate immunity, and phenylethanol glycosides (CPhGs) are among the primary components responsible for this activity. However, the application of CPhGs is negatively… read more here.
Keywords: cphg liposomes; fak; hsc activation; pi3k akt ... See more keywords