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   Articles with "hsc expansion" as a keyword



StemPro™ HSC expansion medium (Prototype) supports superior expansion of human hematopoietic stem-progenitor cells

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.03.448

Abstract: Background & Aim Since numbers of harvested hematopoietic stem cells (HSCs) continues to limit not only laboratory research but also clinical HSC transplantation and gene therapies, development of ex vivo culture systems to expand harvested… read more here.

Keywords: medium prototype; hsc expansion; medium; stempro hsc ... See more keywords

m6A reader suppression bolsters HSC expansion

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recommendations! Published in 2018 at "Cell Research"

DOI: 10.1038/s41422-018-0081-z

Abstract: The functional importance of N-methyladenosine (mA) modification in human health and disease has recently entered the research spotlight. In a recent paper published in Cell Research, Li et al. report a remarkable finding that deficiency… read more here.

Keywords: hscs; hsc expansion; ythdf2 knockout; expansion ... See more keywords

Defining Germline Predisposition to Dnmt3a-Mutant Clonal Hematopoiesis (CH)

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-124530

Abstract: Clonal hematopoiesis (CH) is the result of somatic mutations that confer a selective advantage to hematopoietic stem cells (HSCs), driving them to outcompete other HSCs and dominate mature hematopoietic cell production. While it is estimated… read more here.

Keywords: hsc expansion; dnmt3a; expansion; clonal hematopoiesis ... See more keywords

How HSCs Colonize and Expand in the Fetal Niche of the Vertebrate Embryo: An Evolutionary Perspective

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recommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2019.00034

Abstract: Rare hematopoietic stem cells (HSCs) can self-renew, establish the entire blood system and represent the basis of regenerative medicine applied to hematological disorders. Clinical use of HSCs is however limited by their inefficient expansion ex… read more here.

Keywords: hscs; hsc expansion; hscs colonize; expansion ... See more keywords