Hypoxia preconditioned mesenchymal stem cell-derived exosomes induce ex vivo expansion of umbilical cord blood hematopoietic stem cells CD133+ by stimulation of Notch signalling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology progress"
DOI: 10.1002/btpr.3222
Abstract: Mesenchymal stem cells (MSCs) are crucial cells that play an essential role in the maintenance, self-renewal, and proliferation of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) in the bone marrow niche. It has… read more here.
Keywords: hscs; hematopoietic stem; msc; stem ... See more keywords
Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.32899
Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer‐related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment… read more here.
Keywords: hepatocellular carcinoma; hscs; activated hscs; hepatic stellate ... See more keywords
Identification and Isolation of Mice and Human Hematopoietic Stem Cells.
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DOI: 10.1007/978-1-4939-8697-2_4
Abstract: Hematopoietic stem cells (HSCs) are multipotent cells capable of differentiating into all types of blood cells. The important feature of the HSCs is their ability to repopulate the complete blood cells after BM ablation. For… read more here.
Keywords: hscs; identification isolation; blood; hematopoietic stem ... See more keywords
Metabolic Regulations in Hematopoietic Stem Cells.
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DOI: 10.1007/978-981-13-7342-8_3
Abstract: One of the bottlenecks of the treatments for malignant hematopoietic disorders is the unavailability of sufficient amount of hematopoietic stem cells (HSCs). HSCs are considered to be originated from the aorta-gonad-mesonephros and gradually migrates into fetal… read more here.
Keywords: hscs; regulations hematopoietic; hematopoietic stem; metabolic regulations ... See more keywords
Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway
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DOI: 10.1007/s10620-019-05798-x
Abstract: Background Autophagy is a self-degrading process. Previously, we showed that insulin-like growth factor binding protein-related protein 1 (IGFBPrP1) is a novel transforming growth factor β 1 (TGF β 1)-interacting factor in liver fibrosis; the role… read more here.
Keywords: protein; hscs; growth factor; autophagy ... See more keywords
In vitro large scale production of megakaryocytes to functional platelets from human hematopoietic stem cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.090
Abstract: Megakaryocytopoiesis results in the formation of platelets, which are essential for hemostasis. Decreased production or increased destruction of platelets can cause thrombocytopenia, in which platelet transfusion is the mode of treatment. The present study is… read more here.
Keywords: hscs; production; human hematopoietic; hematopoietic stem ... See more keywords
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo
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DOI: 10.1016/j.celrep.2018.03.025
Abstract: SUMMARY Somatic mutations in DNMT3A are recurrent events across a range of blood cancers. Dnmt3a loss of function in hematopoietic stem cells (HSCs) skews divisions toward self-renewal at the expense of differentiation. Moreover, DNMT3A mutations… read more here.
Keywords: hscs; dnmt3a; hematopoietic stem; stem cells ... See more keywords
Fighting liver fibrosis to reduce mortality associated with chronic liver diseases: The importance of new molecular targets and biomarkers
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.02.002
Abstract: The past 30 years have seen major progress in the knowledge plays a fundamental role in fibrogenesis,mainly by inducingHSC activaand management of liver disease. Unfortunately, millions of people worldwide still suffer from chronic hepatic illness.… read more here.
Keywords: hscs; fibrosis; liver fibrosis; mortality ... See more keywords
MECHANISM OF IMPROVED HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT IN NON-CONDITIONED NSGW41 MICE
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DOI: 10.1016/j.exphem.2019.06.425
Abstract: Humanized mouse models enable the study of human hematopoietic stem cell (HSC) function in vivo. However, human HSC engraftment and self-renewal are still hampered in xenotransplantation settings restricting the study of mechanisms regulating human HSC… read more here.
Keywords: engraftment; stem cell; nsgw41 mice; hscs ... See more keywords
3113 – HEMATOPOIETIC STEM CELL DYNAMICS IN A NON-IRRADIATED TRANSPLANTATION MODEL
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DOI: 10.1016/j.exphem.2020.09.123
Abstract: Hematopoietic stem cells (HSCs) are defined as the cells that have the ability of both multi-potency and self-renewal. This property of HSCs has traditionally been characterized by transplantation assays where the donor HSCs are transferred… read more here.
Keywords: hscs; model; transplantation; hematopoietic system ... See more keywords
Directional capacity of Human Mesenchymal Stem Cells to support Hematopoietic Stem Cell proliferation in vitro.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146218
Abstract: OBJECTIVES Hematopoietic stem cells (HSCs) reside in a specialised microenvironment in the bone marrow, which is majorly composed of mesenchymal stem cells (MSCs) and its' derivatives. This study aimed to investigate the regulatory role of… read more here.
Keywords: stem; proliferation; stem cells; hscs ... See more keywords