Association of 11β-hydroxysteroid dehydrogenase type1 (HSD11b1) gene polymorphisms with outcome of antidepressant therapy and suicide attempts
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112343
Abstract: The hypothalamic-pituitary-adrenal axis has been implicated in the pathophysiology of depressive disorders. HSD11B1 encodes 11β-hydroxysteroid dehydrogenase type1 enzyme, responsible for converting cortisone to cortisol. Genetic polymorphisms in HSD11B1 may impact in depression outcome and risk… read more here.
Keywords: risk; hsd11b1; suicide; association ... See more keywords
Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population.
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes research and clinical practice"
DOI: 10.1016/j.diabres.2017.07.011
Abstract: BACKGROUND 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) is an NADP or NADPH-dependent enzyme that generates cortisol from cortisone for a local glucocorticoid action. Functional polymorphisms within 11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene have shown an association… read more here.
Keywords: hsd11b1; association; association hsd11b1; hsd11b1 rs12086634 ... See more keywords
Transient expansion of the expression region of Hsd11b1, encoding 11β-hydroxysteroid dehydrogenase type 1, in the developing mouse neocortex.
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DOI: 10.1111/jnc.15505
Abstract: Corticosteroids are stress-related hormones that maintain homeostasis. The most effective corticosteroids are corticosterone (CORT) in rodents and cortisol in primates. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1; EC 1.1.1.146), encoded by Hsd11b1, is a key regulator of… read more here.
Keywords: dehydrogenase type; hsd11b1; developing mouse; cort ... See more keywords
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004150
Abstract: Background Immune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improved… read more here.
Keywords: cell; melanoma; activation; blockade ... See more keywords
Activation of HSD11B1 in the bovine cumulus-oocyte complex during IVM and IVF
Sign Up to like & getrecommendations! Published in 2019 at "Endocrine Connections"
DOI: 10.1530/ec-19-0188
Abstract: The bovine cumulus-oocyte complex (COC) is capable of converting cortisone, an inert glucocorticoid to active cortisol. This mechanism is mediated by 11β-hydroxysteroid oxidoreductase type 1 (HSD11B1), whose expression dramatically increases in the mature COC. In… read more here.
Keywords: bovine cumulus; bovine; ivf; coc ... See more keywords